Document Detail

Short- and Long-Term Individual Variation in NT-proBNP levels in Patients with Stable Coronary Artery Disease.
MedLine Citation:
PMID:  23566928     Owner:  NLM     Status:  Publisher    
BACKGROUND: In addition to diagnosis of heart failure (HF) natriuretic peptides (BNP and NT-proBNP) may be used for risk prediction in stable and acute coronary artery disease. The aim of the study was to evaluate the short- and long-term individual variation of NT-proBNP in patients with stable coronary artery disease. METHODS: Twenty-four patients with suspected stable coronary artery disease and scheduled for elective coronary angiography were included. Blood samples were drawn at enrolment and, on average 3 weeks later, serially the day prior to coronary angiography. NT-proBNP was determined using Elecsys proBNP sandwich immunoassay (Roche Diagnostics). RESULTS: The individual variation in NT-proBNP over 4 hours was 11.8%, over 20 hours 12.4% and over 3 weeks 20.4%. The corresponding positive and negative lognormal reference change values (RCV) were +41/-29%, +42/-30% and +76/-43%, respectively. No significant circadian variation was found. CONCLUSIONS: Our results suggest that an increase in NT-proBNP levels of >42 % or a decrease of >30% is needed to indicate a reliable short-term change; and for long-term change an increase of >76% or a decrease of >43 % is required. This should be considered when interpreting changes in NT-proBNP levels.
Anna M Nordenskjöld; Håkan Ahlström; Kai M Eggers; Ole Fröbert; Per Venge; Bertil Lindahl
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-5
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
Department of Cardiology, Örebro University Hospital, Örebro, Sweden. Electronic address:
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