Document Detail

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells.
MedLine Citation:
PMID:  22669487     Owner:  NLM     Status:  Publisher    
Short-chain fatty acids (SCFAs) produced by the colonic bacterial fermentation of dietary fiber contribute a significant proportion of daily energy requirement. Furthermore, these compounds are modulators of macrophage function and potential targets for the development of new drugs. The aims of this study were to evaluate the effects of three types of SCFAs (sodium acetate (NaAc), sodium propionate (NaP), and sodium butyrate (NaB)) on the production of NO and inducible nitric oxide synthase (iNOS) and proinflammatory and antiinflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin (IL-1, IL-6, and IL-10)) and to observe the effect of NaAc on inhibiting lipopolysaccharide (LPS)-induced NF-κB activation in LPS-stimulated RAW264.7 cells. The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-α, IL-1β, IL-6, and NO, and inhibited the vitality of iNOS. Meanwhile, SCFAs enhanced the production of antiinflammatory cytokine IL-10 in lower concentrations (1-1,200 μmol/L). Like NaB, NaAC inhibited LPS-induced NF-κB activation. These results may hold promise on the role that SCFAs have on the prevention and treatment of various inflammatory conditions.
Tengfei Liu; Jing Li; Yuxin Liu; Nan Xiao; Haitao Suo; Kun Xie; Chunliu Yang; Chen Wu
Related Documents :
22734127 - Natural killer cells and their receptors in multiple sclerosis.
22657407 - Rhinovirus 16-induced ifn-α and ifn-β are deficient in bronchoalveolar lavage cells in ...
22345097 - The novel akt inhibitor api-1 induces c-flip degradation and synergizes with trail to a...
22527937 - Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting stat3 and...
21292197 - Kinetics and involvement of interleukin-17 in the outcome of peritonitis in nondiabetic...
23594597 - Keratinocyte-specific deletion of the receptor rage modulates the kinetics of skin infl...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-5
Journal Detail:
Title:  Inflammation     Volume:  -     ISSN:  1573-2576     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Cell Pharmacology, College of Pharmaceutical Sciences, Hebei University, 180 East Wusi Road, Baoding, 071002, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Osteoblast proliferation and differentiation on a barrier membrane in combination with BMP2 and TGF?...
Next Document:  Effect of feed flushing during summer season on growth, reproductive performance and blood metabolit...