Document Detail

Short-axis 2D strain from speckle tracking predicts echocardiographic response to cardiac resynchronization therapy.
MedLine Citation:
PMID:  21175779     Owner:  NLM     Status:  MEDLINE    
AIMS: Two-dimensional (2D) strain imaging from speckle tracking is a Doppler independent technique allowing assessment of left ventricular (LV) strain (ɛ); systolic strain rate (SRs') and early diastolic strain rate (SRe') in the radial and circumferential planes. We set out to investigate whether (i) these parameters facilitated assessment of dyssynchronous contraction and (ii) these measures could predict response to cardiac resynchronization therapy (CRT).
METHODS AND RESULTS: Forty-one patients with severe, symptomatic heart failure on optimal medical therapy were recruited. Thirty-two healthy subjects were used as controls. Time to peak ɛ, SRs', and SRe' of 6 LV segments were measured in the parasternal short axis prior to and 6 weeks post CRT implantation. Time delays between segments were then calculated and ANOVA assessed for prediction of response, classified as reduction in LV end systolic volume of >15%. 2D strain demonstrated significantly more dyssynchronous contraction in the heart failure population at baseline compared to healthy controls. Significant reduction in dyssynchrony was seen in ɛ and SRs' following CRT, largely confined to those with evidence of remodeling. The time delay between peak circumferential SRs' of opposing walls was the best predictor of reverse remodeling.
CONCLUSION: 2D strain imaging appears to be a useful measure to predict response to CRT. The time to peak circumferential SR is a new predictor of response.
Nigel J Artis; David L Oxborough; Karen M Birch; Gordon Williams; Lip-Bun Tan; Christopher B Pepper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-22
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  28     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-05-02     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-84     Citation Subset:  IM    
Copyright Information:
© 2010, Wiley Periodicals, Inc.
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MeSH Terms
Aged, 80 and over
Cardiac Resynchronization Therapy*
Middle Aged
Predictive Value of Tests
Ventricular Dysfunction / ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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