Document Detail


Shocks from pacemaker cardioverter defibrillators increase with amiodarone in patients at high risk for sudden cardiac death.
MedLine Citation:
PMID:  14631135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of amiodarone used in combination with a pacemaker cardioverter defibrillator (PCD) to decrease episodes of ventricular tachycardia and subsequent PCD shocks is not clear. We examined a retrospective registry of 82 patients with PCD implantation to define the efficacy of amiodarone treatment. We compared patients treated with amiodarone (for 24 consecutive months without interruption) versus no amiodarone. In patients treated with amiodarone there was a 3-fold increase (p = 0.02) in PCD shocks; in patients not on beta-blockers, amiodarone resulted in a 6-fold increase (p < 0.05) in PCD shocks. Patients with a left ventricular ejection fraction >30% on amiodarone and patients <72 years old had increases (p < 0.05) in PCD shocks. In conclusion, patients treated with amiodarone had more PCD shocks than those not treated. These findings are unexpected and merit a prospective study.
Authors:
Abhijit A Shinde; Elizabeth B Juneman; Brian Mitchell; Mary K Pierce; Mohamed A Gaballa; Steven Goldman; Hoang Thai
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  100     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2003  
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Affiliation:
Section of Cardiology, Department of Medicine, Southern Arizona VA Health Care System and Sarver Heart Center, University of Arizona, Tucson, AZ 85723, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amiodarone / adverse effects*,  therapeutic use
Case-Control Studies
Death, Sudden, Cardiac / prevention & control*
Defibrillators, Implantable
Dose-Response Relationship, Drug
Drug Administration Schedule
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Pacemaker, Artificial*
Probability
Reference Values
Registries
Retrospective Studies
Risk Assessment
Severity of Illness Index
Shock, Cardiogenic / epidemiology,  etiology*
Survival Analysis
Tachycardia, Ventricular / diagnosis,  mortality,  therapy*
Chemical
Reg. No./Substance:
1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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