| Shocks from pacemaker cardioverter defibrillators increase with amiodarone in patients at high risk for sudden cardiac death. | |
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MedLine Citation:
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PMID: 14631135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of amiodarone used in combination with a pacemaker cardioverter defibrillator (PCD) to decrease episodes of ventricular tachycardia and subsequent PCD shocks is not clear. We examined a retrospective registry of 82 patients with PCD implantation to define the efficacy of amiodarone treatment. We compared patients treated with amiodarone (for 24 consecutive months without interruption) versus no amiodarone. In patients treated with amiodarone there was a 3-fold increase (p = 0.02) in PCD shocks; in patients not on beta-blockers, amiodarone resulted in a 6-fold increase (p < 0.05) in PCD shocks. Patients with a left ventricular ejection fraction >30% on amiodarone and patients <72 years old had increases (p < 0.05) in PCD shocks. In conclusion, patients treated with amiodarone had more PCD shocks than those not treated. These findings are unexpected and merit a prospective study. |
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Authors:
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Abhijit A Shinde; Elizabeth B Juneman; Brian Mitchell; Mary K Pierce; Mohamed A Gaballa; Steven Goldman; Hoang Thai |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cardiology Volume: 100 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 2003 |
Date Detail:
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Created Date: 2003-11-21 Completed Date: 2004-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 143-8 Citation Subset: IM |
Affiliation:
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Section of Cardiology, Department of Medicine, Southern Arizona VA Health Care System and Sarver Heart Center, University of Arizona, Tucson, AZ 85723, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / adverse effects*, therapeutic use Case-Control Studies Death, Sudden, Cardiac / prevention & control* Defibrillators, Implantable Dose-Response Relationship, Drug Drug Administration Schedule Humans Logistic Models Male Middle Aged Multivariate Analysis Pacemaker, Artificial* Probability Reference Values Registries Retrospective Studies Risk Assessment Severity of Illness Index Shock, Cardiogenic / epidemiology, etiology* Survival Analysis Tachycardia, Ventricular / diagnosis, mortality, therapy* |
| Chemical | |
Reg. No./Substance:
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1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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