Document Detail


Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart.
MedLine Citation:
PMID:  17913335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It is currently accepted that the isolation, expansion and application of resident cardiac stem cells may hold therapeutic promise for the future. Recently, it has been demonstrated that shock waves (SW) could enhance the expression of vascular endothelial growth factor (VEGF) and its receptor, Flt-1. As the development of angiogenic noninvasive therapy is very important for future therapeutic strategies in cardiovascular diseases, we examined in vitro, the effects of SW treatment on adult resident cardiac primitive cells isolated from bioptic fragments of normal human hearts and from explanted pathologic hearts with postischemic cardiomyopathy. This study demonstrates that SW have positive influence on both the proliferation and the differentiation of cardiomyocytes, smooth muscle and endothelial cells precursors, with a more obvious effect being evident in the cells from normal heart than in those taken from pathologic hearts. Our results suggest that SW treatment could inhibit or retard the pathologic remodeling and functional degradation of the heart if applied during the early stages of heart failure.
Authors:
Daria Nurzynska; Franca Di Meglio; Clotilde Castaldo; Alessandro Arcucci; Ernst Marlinghaus; Sergio Russo; Bruno Corrado; Luca de Santo; Francesco Baldascino; Maurizio Cotrufo; Stefania Montagnani
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-10-29
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  34     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  334-42     Citation Subset:  IM    
Affiliation:
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / analysis
Cardiomyopathy, Dilated / metabolism,  pathology,  therapy
Cell Differentiation
Cell Lineage
Cell Proliferation
Cells, Cultured
Female
Humans
Lithotripsy*
Male
Middle Aged
Myocardium / chemistry,  cytology*,  pathology
Stem Cells / physiology*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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