Document Detail


Shock-induced figure-of-eight reentry in the isolated rabbit heart.
MedLine Citation:
PMID:  10576949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The patterns of transmembrane potential on the whole heart during and immediately after fibrillation-inducing shocks are unknown. To study arrhythmia induction, we recorded transmembrane activity from the anterior and posterior epicardial surface of the isolated rabbit heart simultaneously using 2 charge-coupled device cameras (32,512 pixels, 480 frames/second). Isolated hearts were paced from the apex at a cycle length of 250 ms. Two shock coils positioned inside the right ventricle (-) and atop the left atrium (+) delivered shocks at 3 strengths (0.75, 1.5, and 2.25 A) and 6 coupling intervals (130 to 230 ms). The patterns of depolarization and repolarization were similar, as is evident in the uniformity of action potential duration at 75% repolarization (131.4¿8.3 ms). At short coupling intervals (<180 ms), shocks hyperpolarized a large portion of the ventricles and produced a pair of counterrotating waves, one on each side of the heart. The first beat after the shock was reentrant in 90% of short coupling interval episodes. At long coupling intervals (>180 ms), increasingly stronger shocks depolarized an increasingly larger portion of the heart. The first beat after the shock was reentrant in 18% of long coupling interval episodes. Arrhythmias were most often induced at short coupling intervals (98%) than at long coupling intervals (35%). The effect and outcome of the shock were related to the refractory state of the heart at the time of the shock. Hyperpolarization occurred at short coupling intervals, whereas depolarization occurred at long coupling intervals. Consistent with the "critical point" hypothesis, increasing shock strength and coupling interval moved the location where reentry formed (away from the shock electrode and pacing electrode, respectively).
Authors:
I Banville; R A Gray; R E Ideker; W M Smith
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  85     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-04     Completed Date:  1999-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  742-52     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Ala, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Cardiac Pacing, Artificial
Electrophysiology
Electroshock*
Rabbits
Reaction Time
Reproducibility of Results
Ventricular Fibrillation / etiology*,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL-28429/HL/NHLBI NIH HHS

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