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Shinzami Korean purple-fleshed sweet potato extract prevents ischemia-reperfusion-induced liver damage in rats.
MedLine Citation:
PMID:  25428031     Owner:  NLM     Status:  Publisher    
BACKGROUND: This study was designed to investigate the hepatoprotective effect of extract from Shinzami, a variety of purple sweet potato, in rats injured by hepatic ischemia reperfusion (I/R).
RESULTS: Pretreatment with Shinzami extract decreased the aspirate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels in our hepatic I/R rat model. The glutathione (GSH) level and superoxide dismutase (SOD) activity level were significantly higher in the rats pretreated with the Shinzami extract compared with the hepatic I/R rats, and the glutathione peroxidase (GSH-Px) activity level was higher in pretreated rats. The total anthocyanins extracted from Shinzami, however, only increased the SOD activity level in the hepatic I/R rats. Rats pretreated with the Shinzami extract or anthocyanins demonstrated attenuated hepatic pathological changes, such as hepatic distortion, hemorrhage, necrosis and inflammatory cell infiltration compared with the hepatic I/R control rats.
CONCLUSION: Shinzami extract and anthocyanins have a hepatoprotective effect on the liver damage induced by hepatic I/R by improving antioxidant status. Furthermore, the Shinzami extract may have a more potent effect on the antioxidant status compared with the Shinzami anthocyanins alone.
Saet-Byeol Jung; Jae-Ho Shin; Ji Yeon Kim; Oran Kwon
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-26
Journal Detail:
Title:  Journal of the science of food and agriculture     Volume:  -     ISSN:  1097-0010     ISO Abbreviation:  J. Sci. Food Agric.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  0376334     Medline TA:  J Sci Food Agric     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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