Document Detail


Shining light on materials--a self-sterilising revolution.
MedLine Citation:
PMID:  22819684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review focuses on the development of light activated antimicrobial surfaces. These surfaces kill microbes by the action of light and have potential applications in domestic and healthcare settings. The inspiration for the new self-cleaning surfaces originates from photodynamic therapy where light is used to locate and destroy tumours. The first generation photosensitiser molecules, based on a porphyrin ring structure, could be considered as bioinspired and chemically related to chlorophyll. The review looks at developments of both soft polymeric surfaces with either surface bound or impregnated photosensitiser molecules; and hard inorganic surfaces such as modified titanium dioxide. The bacterial kill mechanisms are looked into with both surface types showing primary microbial kill through a radical induced pathway. The hard inorganic surfaces also show low bacterial adherence by means of a light activated photo-wetting of the surfaces meaning that they are "Easy Clean" and wash off microbes uniformly.
Authors:
Sacha Noimark; Charles W Dunnill; Ivan P Parkin
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-20
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  65     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-05-06     Completed Date:  2013-09-27     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  570-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Light
Manufactured Materials*
Photosensitizing Agents
Polymers
Sterilization / instrumentation*,  methods
Surface Properties
Titanium
Grant Support
ID/Acronym/Agency:
G0902208//Medical Research Council
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 0/Polymers; 15FIX9V2JP/titanium dioxide; D1JT611TNE/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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