Document Detail


Shigellosis of childhood in northern Greece: epidemiological, clinical and laboratory data of hospitalized patients during the period 1971-96.
MedLine Citation:
PMID:  10826910     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate epidemiological, clinical and laboratory data of shigellosis in children from northern Greece, hospitalized in our department during the period 1971-96. In total, 422 cases of shigellosis, aged 1 month to 14 y (238M, 184F) were hospitalized during the study period. The annual distribution was approximately stable until 1990, the mean number of cases per year being about 20. During the last 4 y the incidence significantly decreased. Shigella was serotyped in 138/422 cases. Seventy six of the strains were S. flexneri (55%) and 56 S. sonnei (40%). In the majority of cases the clinical picture was mild. Severe dehydration was seen in only 6 patients. Ninety four patients (22%) had extra-intestinal manifestations. Most common of these were convulsions (16%) and, less frequently, disturbances of consciousness (n = 26), rash (n = 9), shock and disseminated intravascular coagulopathy (n = 2), nerve paralysis (n = 2), severe anaemia (n = 2) and haemolytic-uraemic syndrome (n = 1). Nine patients had acute encephalopathy of 12 h to 12 d duration. It is important to note that all these cases recovered completely with no residual neurological deficit, except for 1 girl who developed temporal epilepsy 8 y later. Spinal fluid was normal in all 42 examined patients. Antibiotics were given to 212 of 422 patients, mainly during the first half of the study period. Shigella resistance to antibiotic was significant for cotrimoxazole (24%) and ampicillin (16%). All patients were cured. Shigellosis is a mild disease in our area, with a decreasing prevalence.
Authors:
J Kavaliotis; S Karyda; T Konstantoula; A Kansouzidou; H Tsagaropoulou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  32     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-19     Completed Date:  2000-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Hospital for Infectious Diseases, Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Ampicillin / pharmacology,  therapeutic use
Anemia / pathology
Anti-Bacterial Agents / pharmacology,  therapeutic use
Child
Child, Preschool
Consciousness Disorders / pathology
Dehydration / pathology
Disseminated Intravascular Coagulation / pathology
Drug Resistance, Microbial
Dysentery, Bacillary / diagnosis,  epidemiology*,  microbiology
Exanthema / pathology
Female
Greece / epidemiology
Hemolytic-Uremic Syndrome / pathology
Humans
Incidence
Infant
Male
Paresis / pathology
Penicillins / pharmacology,  therapeutic use
Seizures / pathology
Shigella / drug effects,  isolation & purification*
Shock / pathology
Trimethoprim-Sulfamethoxazole Combination / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Penicillins; 69-53-4/Ampicillin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

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