| Shiga toxins. | |
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MedLine Citation:
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PMID: 11595626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Shiga toxin and Shiga-like toxins belong to the group of protein toxins which have a moiety that binds to the cell surface and another enzymatically active moiety that after entry into the cytosol inhibits protein synthesis enzymatically. The toxins can also cause apoptosis by mechanisms that may be different from the effect on the protein synthesis machinery. Shigella dysenteriae, some strains of Escherichia coli as well as other bacteria can secrete such toxins which cause serious complications during infections. An increasing knowledge about the toxins and their interactions with cells is important both for treatment of disease, and for elucidation of pathways of intracellular transport. |
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Authors:
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K Sandvig |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 39 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2001-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 1629-35 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway. ksandvig@radium.uio.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Protein Synthesis Inhibitors / toxicity Shiga Toxin / metabolism, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Protein Synthesis Inhibitors; 75757-64-1/Shiga Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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