Document Detail


Shifts in the TH1/TH2 balance during human pregnancy correlate with apoptotic changes.
MedLine Citation:
PMID:  9588218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An important prerequisite for a successful pregnancy is that the maternal immune system does not reject the fetus. Down-regulation of the T helper 1 (TH1) associated cellular immune response could therefore be essential. With flow cytometric techniques, we show on a single cell level that both CD4+ and CD8+ T cells from peripheral blood produce less TH1 cytokines (i.e. IFN-gamma and IL-2) and more TH2 cytokines (i.e. IL-4) during normal human pregnancy and shortly after delivery than during non-pregnancy. The TH1/TH2 cytokine ratio in T cells of women during pregnancy and after delivery was significantly decreased. In contrast the TH1/TH2 ratio was elevated to near normal in women with recurrent spontaneous abortions, indicating a marked shift towards TH1 immunity. Fas antigen (CD95) on T cells was significantly elevated during pregnancy and in the post-delivery phase whereas the intracellular expression of anti-apoptotic protein Bcl-2 remained unchanged. Nevertheless Fas-mediated apoptosis in T cells was markedly reduced during normal human pregnancy. We hypothesize that TH1 cells undergo predominantly Fas-mediated apoptosis during pregnancy as has been shown in some TH2-prone diseases (e.g. SLE, HIV) where an elevated Fas expression on peripheral T cells is observed. This could explain the exacerbated occurrence of TH2-associated diseases in pregnancy.
Authors:
G Reinhard; A Noll; H Schlebusch; P Mallmann; A V Ruecker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  245     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-05     Completed Date:  1998-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  933-8     Citation Subset:  IM; X    
Affiliation:
Department of Clinical Biochemistry, University of Bonn, Germany. lab04@mailer.meb.uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD95 / biosynthesis
Apoptosis*
Down-Regulation*
Female
Humans
Interferon-gamma / biosynthesis
Interleukin-2 / biosynthesis
Interleukin-4 / biosynthesis
Lymphocyte Count
Pregnancy / immunology*
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
Th1 Cells / physiology*
Th2 Cells / physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Interleukin-2; 0/Proto-Oncogene Proteins c-bcl-2; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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