| Shifted helical computed tomography to optimize cardiac positron emission tomography-computed tomography coregistration: quantitative improvement and limitations. | |
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MedLine Citation:
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PMID: 20868626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography-computed tomography (PET-CT) uses CT attenuation correction but suffers from misregistration artifacts. However, the quantitative accuracy of helical versus cine CT in the same patient after optimized coregistration by shifting both CT data as needed for each patient is unknown. We studied 293 patients undergoing cardiac perfusion PET-CT using helical CT attenuation correction for comparison to cine CT. Objective, quantitative criteria identified perfusion abnormalities that were associated visually with PET-CT misregistration. Custom software shifted CT data to optimize coregistration with quantitative artifact improvement. The majority (58.1%) of cases with both helical and shifted helical CT data (n = 93) had artifacts that improved or resolved by software shifting helical CT data. Translation of shifted helical CT was greatest in the x-direction (8.8 ± 3.3 mm) and less in the y- and z-directions (approximately 3.5 mm). The magnitude of differences in quantitative end points was greatest for helical (p = .0001, n = 177 studies), less for shifted helical but significant (p = .0001, n = 93 studies), and least for cine (not significant, n = 161 studies) CT compared to optimal attenuation correction for each patient. Frequent artifacts owing to attenuation-emission misregistration are substantially corrected by software shifting helical CT scans to achieve proper coregistration that, however, remains on average significantly inferior to cine CT attenuation quantitatively. |
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Authors:
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Nils P Johnson; Tinsu Pan; K Lance Gould |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging Volume: 9 ISSN: 1536-0121 ISO Abbreviation: Mol Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-12 Revised Date: 2011-04-07 |
Medline Journal Info:
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Nlm Unique ID: 101120118 Medline TA: Mol Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 256-67 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Positron-Emission Tomography / methods* Software Tomography, Spiral Computed / methods* |
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