Document Detail


Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: a longitudinal study with near-infrared spectroscopy.
MedLine Citation:
PMID:  17681629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Motor functional recovery after stroke may be attributable to cerebral reorganization. We used near-infrared spectroscopy, which measures non-invasively the changes in oxy- and deoxy-hemoglobin concentrations in response to neural activation, for monitoring cerebral activation in stroke patients, and investigated the longitudinal changes in functional laterality of activations in the primary sensorimotor cortex during unilateral audio-paced (1 Hz) hand movement. We examined five ischemic stroke patients (4 females and 1 male, 52-67 years old) with mild to moderate hemiparesis at acute stages and chronic stages at least 1 month later. Normal subjects (3 females and 2 males, 47-63 years old) were also included. Unilateral hand movement activated predominantly the contralateral primary sensorimotor cortex in the normal subjects and the stroke patients when they moved unaffected hand. Affected hand movements activated bilateral sensorimotor cortices early after stroke (< 25 days of stroke onset), whereas the activation pattern returned toward normal at later periods (> 35 days). The contralaterality index (0.34 +/- 0.12 in normal control) was reduced at early periods (0.00 +/- 0.03, p < 0.01) after stroke, and returned to normal (0.35 +/- 0.24) as motor function recovered. These findings suggest that a transient increase in motor activation in the ipsilateral intact hemisphere within 1 month may play an important role in the recovery from motor dysfunction after stroke.
Authors:
Kotaro Takeda; Yukihiro Gomi; Itsuki Imai; Nobuaki Shimoda; Masao Hiwatari; Hiroyuki Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-20
Journal Detail:
Title:  Neuroscience research     Volume:  59     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  136-44     Citation Subset:  IM    
Affiliation:
Department of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Brain Mapping
Cerebral Infarction / physiopathology*
Cerebrovascular Circulation / physiology
Dominance, Cerebral / physiology*
Female
Functional Laterality / physiology
Hand / innervation,  physiopathology
Humans
Longitudinal Studies
Male
Middle Aged
Motor Activity / physiology
Motor Cortex / anatomy & histology,  physiopathology*
Movement / physiology
Neuronal Plasticity / physiology
Paresis / etiology,  physiopathology*
Pyramidal Tracts / anatomy & histology,  physiopathology
Recovery of Function / physiology*
Somatosensory Cortex / physiology
Spectroscopy, Near-Infrared / methods*
Time Factors
Volition / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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