Document Detail


Shift from noradrenaline to adrenaline production in the adrenal gland of the lizard, Podarcis sicula, after stimulation with vasoactive intestinal peptide (VIP).
MedLine Citation:
PMID:  12714015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the distribution and function of VIP in the adrenal gland of the lizard, Podarcis sicula. We have shown by immunohistochemistry that VIP fibers were localized exclusively around clusters of chromaffin cells in the dorsal ribbon of the lizard adrenal gland. Moreover, a strong positivity for this peptide was observed within ganglial cells and within most chromaffin cells of the gland. To investigate the effects of VIP on the adrenal gland, we have treated lizards with several doses of this peptide and we have shown that injections of exogenous VIP increased plasma levels of catecholamines and corticosteroids, but not of ACTH. This probably suggests a direct effect of VIP on the control of adrenal hormone secretion without the involvement of the hypothalamo-hypophyseal axis. Our results also establish that the increased levels of the hormones were modulated in a time- and dose-dependent manner. Therefore, our morphological studies showed a clear increased function of steroidogenic cells. In the medullary region, VIP administration induced not only a functional enhancement of adrenaline release from adrenergic cells, but also a shift of noradrenaline cells to adrenaline ones.
Authors:
M De Falco; R Sciarrillo; A Capaldo; V Laforgia; L Varano; G Cottone; A De Luca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  131     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-25     Completed Date:  2004-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-37     Citation Subset:  IM    
Affiliation:
Department of Evolutive and Comparative Biology, University Federico II, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / blood
Adrenal Glands / anatomy & histology,  metabolism*,  ultrastructure
Adrenocorticotropic Hormone / blood
Animals
Chromaffin Cells / drug effects,  metabolism
Dose-Response Relationship, Drug
Epinephrine / biosynthesis*
Female
Immunohistochemistry
Lizards / metabolism*
Male
Microscopy, Electron
Norepinephrine / biosynthesis*
Phenylethanolamine N-Methyltransferase / metabolism
Sex Characteristics
Stimulation, Chemical
Time Factors
Vasoactive Intestinal Peptide / pharmacology*
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 37221-79-7/Vasoactive Intestinal Peptide; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 9002-60-2/Adrenocorticotropic Hormone; EC 2.1.1.28/Phenylethanolamine N-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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