| Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease. | |
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MedLine Citation:
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PMID: 17556025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To identify factors related to progression to CMV end-organ disease, cytokine production, proliferative capacity and phenotype of CMV-specific CD4(+) T-cells were analysed longitudinally. Numbers of IFNgamma(+)CD4(+) and IFNgamma(+)IL-2(+)CD4(+) T-cells tended to decrease in individuals progressing to AIDS with CMV end-organ disease (AIDS-CMV), whereas they remained detectable in long-term asymptomatics (LTAs) and progressors to AIDS with opportunistic infections (AIDS-OI). In parallel, CMV-specific proliferative capacity was lost in AIDS-CMV. Initially, the majority of the CMV-specific IFNgamma(+)CD4(+) T-cells were of the CD45RO(+)CD27(-) subset, but during progression to AIDS-CMV a shift in phenotype to the CD45RO(-)CD27(-) subset was observed. Our data indicate that a decrease in CMV-specific cytokine production and proliferative capacity precedes progression to AIDS-CMV. Accumulation of CD4(+) T-cells with a CD45RO(-)CD27(-) phenotype suggests that persistent antigen exposure drives differentiation of CMV-specific CD4(+) T-cells towards a poorly proliferating, and highly differentiated "effector" subset, which eventually fails to produce IFNgamma in patients developing AIDS-CMV. |
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Authors:
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Corine Bronke; Christine A Jansen; Geertje H A Westerlaken; Iris M De Cuyper; Frank Miedema; Kiki Tesselaar; Debbie van Baarle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-06 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 124 ISSN: 1521-6616 ISO Abbreviation: Clin. Immunol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-20 Completed Date: 2007-09-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 190-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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complications,
immunology*,
virology Antigens, CD27 / immunology* Antigens, CD45 / immunology* CD4-Positive T-Lymphocytes / immunology* Cytomegalovirus / immunology* Cytomegalovirus Infections / immunology*, virology Disease Progression HIV Infections / complications, immunology*, virology HIV-1 / immunology* Humans Interferon-gamma / biosynthesis, immunology Interleukin-2 / biosynthesis, immunology Lymphocyte Activation |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD27; 0/Interleukin-2; 82115-62-6/Interferon-gamma; EC 3.1.3.48/Antigens, CD45 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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