Document Detail

Sheep erythrocytes binding ability on a mouse renal adenocarcinoma cell line and its hybrid with human lymphocytes.
MedLine Citation:
PMID:  825339     Owner:  NLM     Status:  MEDLINE    
A mouse renal adenocarcinoma (Rag) cell line, not related to L cells, rosette with erythrocytes from sheep and mice. The Rag-cell rosettes are performed in suspension and on coverslips. Microscopically they rosette like human T cell. No virus-like particles thus far have been found between the rosetted cells. However, the sheep erythrocyte binding ability of Rag cells are very different as compared to human T cells. The former cannot be impaired by trypsin-EDTA treatment nor inhibited by rabbit anti-human thymocyte immunoglobulin, sodium azide or sodium iodoacetate. Two hybrid clones isolated between Rag-human lymphocytes show similar rosette characteristics as the Rag cells.
P S Lin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  26     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-28     Completed Date:  1977-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  340-5     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / immunology*
Antilymphocyte Serum
Azides / pharmacology
Cell Line
Edetic Acid / pharmacology
Erythrocytes / immunology*
Hybrid Cells / immunology
Iodoacetates / pharmacology
Kidney Neoplasms / immunology*
Microscopy, Electron
Neoplasms, Experimental / immunology
Sheep / immunology
T-Lymphocytes / immunology
Reg. No./Substance:
0/Antilymphocyte Serum; 0/Azides; 0/Iodoacetates; 60-00-4/Edetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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