| Sheehan's syndrome as a rare cause of anaemia secondary to hypopituitarism. | |
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MedLine Citation:
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PMID: 18797868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although its exact mechanism is unclear, anaemia is well recognised as a feature of hypopituitarism; and anaemia is associated with Sheehan's syndrome (SS). We aimed to evaluate the frequency and severity of anaemia and other haematological changes among patients with Sheehan's syndrome, in comparison with healthy controls. Sixty-five SS patients and 55 age-matched female healthy controls were included. Biochemical and hormonal assessments and haematological evaluations were carried out, and groups were compared. The mean number of red blood cells, as well as mean haemoglobin, iron and erythropoietin levels, total iron-binding capacity and transferrin saturation were all significantly lower in SS patients compared to controls. SS patients had significantly higher rates of anaemia (80.0% vs. 25.5%, p = 0.0001), iron deficiency (44.6% vs. 5.4%, p = 0.001), leukopenia (20.0% vs. 5.4%, p = 0.015), thrombocytopenia (9.2% vs. 0.0%, p = 0.028) and bicytopenia (21.5% vs. 1.8%, p = 0.001) compared to controls. Anaemic SS patients had normochromic-normocytic anaemia (55%) or hypochromic-microcytic anaemia (45%). Anaemia is frequently associated with Sheehan's syndrome and responds to appropriate replacement therapy. Hypopituitarism should be considered as a possible cause of anaemia, and a hormone examination should be undertaken promptly, particularly in patients with anaemia resistant to therapy and/or with a history suggestive of Sheehan's syndrome. |
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Authors:
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Deniz Gokalp; Alpaslan Tuzcu; Mithat Bahceci; Senay Arikan; Selen Bahceci; Semir Pasa |
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Publication Detail:
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Type: Journal Article Date: 2008-09-17 |
Journal Detail:
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Title: Annals of hematology Volume: 88 ISSN: 1432-0584 ISO Abbreviation: Ann. Hematol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 405-10 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Dicle University School of Medicine, Diyarbakir, Turkey. dgokalp@dicle.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / etiology* Anemia, Iron-Deficiency / etiology Case-Control Studies Female Humans Hypopituitarism / complications* Incidence Leukopenia / etiology Middle Aged Thrombocytopenia / etiology |
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