Document Detail

Shedding oral mucosa.
MedLine Citation:
PMID:  7835059     Owner:  NLM     Status:  MEDLINE    
Four patients presented with asymptomatic gray-white oral mucosal tissues that sloughed and peeled away leaving a normal tissue base. This peeling phenomenon appeared unlike any known oral mucosal disease, although it somewhat resembled leukoedema and chemically irritated oral mucosa due to certain dentifrices and mouthwashes. Examination of biopsy tissue from three of the four cases along with stripped tissue from the fourth case revealed an intraepithelial cleft near the surface of each specimen. The linear cleft ran parallel to the epithelial surface. Foci of adjacent cells displayed intracellular edema, a feature commonly noted in leukoedema. There was evidence of neither acantholysis nor inflammation. The microscopic pattern was unlike the mucosal entities pemphigus vulgaris, mucosal pemphigoid, lichen planus, candidiasis, and mucosal biting. Although the authors questioned the patients in detail regarding all forms of mechanical and chemical trauma, including those from certain dentifrices and mouthwashes, they could not detect causative factors for these lesions.
D J Zegarelli; D N Silvers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  54     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
School of Dental and Oral Surgery, Columbia University, New York, New York.
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MeSH Terms
Middle Aged
Mouth Diseases* / pathology
Mouth Mucosa / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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