| Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 23410046 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Objective: The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient. Materials and methods: We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Results: Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome. |
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Authors:
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Le Fu; Wei Guo; Bingshan Liu; Linlin Sun; Zhenghong Bi; Li Zhu; Xinyan Wang; Bin Liu; Qian Xie; Ke Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: 18 ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: England |
Other Details:
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Languages: eng Pagination: 126-35 Citation Subset: IM |
Affiliation:
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Department of Radiology, Huashan Hospital of Fudan University , Shanghai , China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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