Document Detail


Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer.
MedLine Citation:
PMID:  23410046     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Objective: The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient. Materials and methods: We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Results: Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.
Authors:
Le Fu; Wei Guo; Bingshan Liu; Linlin Sun; Zhenghong Bi; Li Zhu; Xinyan Wang; Bin Liu; Qian Xie; Ke Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  18     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  126-35     Citation Subset:  IM    
Affiliation:
Department of Radiology, Huashan Hospital of Fudan University , Shanghai , China .
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