| Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routes. | |
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MedLine Citation:
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PMID: 16284329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four groups of six calves were infected experimentally with either a low dose of approximately 10(4) colony-forming units (cfu) or a high dose of approximately 10(6) cfu of Mycobacterium bovis. Each dose was delivered by the intranasal and intratracheal routes. More severe disease was observed in the groups inoculated with the high dose. Visible lesions were identified in 21 of the 24 animals, all of which also gave positive skin tests and interferon-gamma (IFN-gamma) responses. Nasal shedding was detected in 15 of the 24 animals and the frequency of shedding was influenced by both the route and the dose of infection; no shedding was observed in the group infected intratracheally with the low dose. Two of the 15 confirmed shedders had no visible lesions at postmortem examination; both of these calves gave IFN-gamma responses but only one was skin test positive. |
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Authors:
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T McCorry; A O Whelan; M D Welsh; J McNair; E Walton; D G Bryson; R G Hewinson; H M Vordermeier; J M Pollock |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Veterinary record Volume: 157 ISSN: 0042-4900 ISO Abbreviation: Vet. Rec. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-14 Completed Date: 2005-12-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0031164 Medline TA: Vet Rec Country: England |
Other Details:
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Languages: eng Pagination: 613-8 Citation Subset: IM |
Affiliation:
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Department of Veterinary Science, Queen's University of Belfast, Stoney Road, Stormont. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Animals Animals, Newborn Cattle Colony Count, Microbial Enzyme-Linked Immunosorbent Assay / veterinary Interferon-gamma / blood Mycobacterium bovis / pathogenicity* Nasal Mucosa / microbiology Severity of Illness Index Skin Tests / veterinary Trachea Tuberculosis, Bovine / immunology, microbiology*, pathology |
| Chemical | |
Reg. No./Substance:
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82115-62-6/Interferon-gamma |
| Comments/Corrections | |
Erratum In:
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Vet Rec. 2005 Dec 24-31;157(26):849 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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