| Shedding light on melanocyte pathobiology in vivo. | |
| | |
MedLine Citation:
|
PMID: 22422936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cutaneous malignant melanoma is rapidly increasing in the developed world and continues to be a challenge in the clinic. Although extensive epidemiologic evidence points to solar UV as the major risk factor for melanoma, there is a significant gap in our knowledge about how this most ubiquitous environmental carcinogen interacts with the largest organ of the mammalian body (skin) at the microenvironmental and molecular level. We review some recent advances that have started to close this gap. |
| | |
Authors:
|
M Raza Zaidi; Edward C De Fabo; Frances P Noonan; Glenn Merlino |
Related Documents
:
|
22542156 - Aspirin and the prevention of colorectal cancer. 22310896 - Metachronous colorectal cancer in taiwan: analyzing 20 years of data from taiwan cance... 3488136 - Cancer control: introduction to a series of reports on strategies and approaches. 3934476 - Clinical effects of enteral and parenteral nutrition preceding cancer surgery. 23612466 - Lung cancer detection with digital chest tomosynthesis: baseline results from the obser... 19903786 - Pik3ca mutations predict local recurrences in rectal cancer patients. |
Publication Detail:
|
Type: Journal Article; Review Date: 2012-03-15 |
Journal Detail:
|
Title: Cancer research Volume: 72 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-04-04 Completed Date: 2012-05-24 Revised Date: 2013-04-03 |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
|
Languages: eng Pagination: 1591-5 Citation Subset: IM |
Copyright Information:
|
©2012 AACR. |
Affiliation:
|
Laboratory of Cancer Biology & Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. zaidir@mail.nih.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals DNA Damage Humans Interferon-gamma / physiology Melanocytes / radiation effects* Melanoma / etiology Neoplasms, Radiation-Induced / etiology Skin Neoplasms / etiology Ultraviolet Rays / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
|
Z99 CA999999/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ef7 Encodes an ELF3-like Protein and Promotes Rice Flowering by Negatively Regulating the Floral Rep...
Next Document: Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibrob...