| Shear wave ultrasound elastography of the prostate: initial results. | |
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MedLine Citation:
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PMID: 22357224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This prospective study was to evaluate shear wave elastography (SWE) in the detection of prostate cancer (PC). METHODS: Patients scheduled for a transrectal ultrasound (TRUS) biopsy of the prostate because of elevated prostate-specific antigen levels or abnormal digital rectal examination result underwent a standard TRUS and SWE. A second TRUS examination and sextant biopsy by a second physician blinded to SWE results was then performed. Pathologic result was reviewed, and sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated. RESULTS: A total of 53 patients (318 sextants) participated in the study. Mean age was 64.2 years (range, 53-79 years). A total of 26 foci of PC were detected in 11 patients (20.7%). On the basis of the receiver operating characteristic curve, a value of 37 kPa was used as the cutoff between benign and malignant. This produced a sensitivity of 96.2% (25/26), a specificity of 96.2% (281/292), a PPV of 69.4% (25/36), and an NPV of 99.6% (281/282). Six (55%) of 11 false-positive samples were secondary to benign calcifications. The Young modulus of PC ranged from 30 to 110 kPa (mean [SD], 58.0 [20.7] kPa). At the patient level, if a cutoff of 40 kPa was used, all PCs would have been detected, and the positive biopsy rate would be 11 (50%) of 22 compared to 11 (20.8%) of 53 without SWE--a 140% increase in the positive biopsy rate. CONCLUSIONS: Shear wave elastography has a high sensitivity, specificity, PPV, and NPV for the detection of PC. With a high PPV, patients with elevated prostate-specific antigen levels or abnormal results in the digital rectal examination and negative SWE may not require biopsy. This could significantly reduce the negative biopsy rate in PC detection. |
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Authors:
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Richard G Barr; Richard Memo; Carl R Schaub |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Ultrasound quarterly Volume: 28 ISSN: 1536-0253 ISO Abbreviation: Ultrasound Q Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-23 Completed Date: 2012-07-16 Revised Date: 2013-01-29 |
Medline Journal Info:
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Nlm Unique ID: 8809459 Medline TA: Ultrasound Q Country: United States |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Northeast Ohio Medical University, Rootstown, OH 44512, USA. rgbarr@zoominternet.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Diagnosis, Differential Elasticity Imaging Techniques / methods* Endosonography* Follow-Up Studies Humans Male Middle Aged Predictive Value of Tests Prospective Studies Prostate / pathology, ultrasonography* Prostatic Neoplasms / pathology, ultrasonography* ROC Curve Rectum |
| Comments/Corrections | |
Comment In:
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J Urol. 2013 Jan;189(1):229
[PMID:
23235238
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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