Document Detail

Shear wave ultrasound elastography of the prostate: initial results.
MedLine Citation:
PMID:  22357224     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This prospective study was to evaluate shear wave elastography (SWE) in the detection of prostate cancer (PC).
METHODS: Patients scheduled for a transrectal ultrasound (TRUS) biopsy of the prostate because of elevated prostate-specific antigen levels or abnormal digital rectal examination result underwent a standard TRUS and SWE. A second TRUS examination and sextant biopsy by a second physician blinded to SWE results was then performed. Pathologic result was reviewed, and sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated.
RESULTS: A total of 53 patients (318 sextants) participated in the study. Mean age was 64.2 years (range, 53-79 years). A total of 26 foci of PC were detected in 11 patients (20.7%). On the basis of the receiver operating characteristic curve, a value of 37 kPa was used as the cutoff between benign and malignant. This produced a sensitivity of 96.2% (25/26), a specificity of 96.2% (281/292), a PPV of 69.4% (25/36), and an NPV of 99.6% (281/282). Six (55%) of 11 false-positive samples were secondary to benign calcifications. The Young modulus of PC ranged from 30 to 110 kPa (mean [SD], 58.0 [20.7] kPa). At the patient level, if a cutoff of 40 kPa was used, all PCs would have been detected, and the positive biopsy rate would be 11 (50%) of 22 compared to 11 (20.8%) of 53 without SWE--a 140% increase in the positive biopsy rate.
CONCLUSIONS: Shear wave elastography has a high sensitivity, specificity, PPV, and NPV for the detection of PC. With a high PPV, patients with elevated prostate-specific antigen levels or abnormal results in the digital rectal examination and negative SWE may not require biopsy. This could significantly reduce the negative biopsy rate in PC detection.
Richard G Barr; Richard Memo; Carl R Schaub
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Ultrasound quarterly     Volume:  28     ISSN:  1536-0253     ISO Abbreviation:  Ultrasound Q     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-23     Completed Date:  2012-07-16     Revised Date:  2013-01-29    
Medline Journal Info:
Nlm Unique ID:  8809459     Medline TA:  Ultrasound Q     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-20     Citation Subset:  IM    
Northeast Ohio Medical University, Rootstown, OH 44512, USA.
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MeSH Terms
Diagnosis, Differential
Elasticity Imaging Techniques / methods*
Follow-Up Studies
Middle Aged
Predictive Value of Tests
Prospective Studies
Prostate / pathology,  ultrasonography*
Prostatic Neoplasms / pathology,  ultrasonography*
ROC Curve
Comment In:
J Urol. 2013 Jan;189(1):229   [PMID:  23235238 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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