| Shear stress related blood damage in laminar couette flow. | |
| | |
MedLine Citation:
|
PMID: 12780506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Artificial organs within the blood stream are generally associated with flow-induced blood damage, particularly hemolysis of red blood cells. These damaging effects are known to be dependent on shear forces and exposure times. The determination of a correlation between these flow-dependent properties and actual hemolysis is the subject of this study. For this purpose, a Couette device has been developed. A fluid seal based on fluorocarbon is used to separate blood from secondary external damage effects. The shear rate within the gap is controlled by the rotational speed of the inner cylinder, and the exposure time by the amount of blood that is axially pumped through the device per given time. Blood damage is quantified by the index of hemolysis (IH), which is calculated from photometric plasma hemoglobin measurements. Experiments are conducted at exposure times from texp=25 - 1250 ms and shear rates ranging from tau=30 up to 450 Pa ensuring Taylor-vortex free flow characteristics. Blood damage is remarkably low over a broad range of shear rates and exposure times. However, a significant increase in blood damage can be observed for shear stresses of tau>or= 425 Pa and exposure times of texp>or= 620 ms. Maximum hemolysis within the investigated range is IH=3.5%. The results indicate generally lower blood damage than reported in earlier studies with comparable devices, and the measurements clearly indicate a rather abrupt (i.e., critical levels of shear stresses and exposure times) than gradual increase in hemolysis, at least for the investigated range of shear rates and exposure times. |
| | |
Authors:
|
Reinhard Paul; Jörn Apel; Sebastian Klaus; Frank Schügner; Peter Schwindke; Helmut Reul |
Related Documents
:
|
21082456 - Flow cell hydrodynamics and their effects on e. coli biofilm formation under different ... 18999716 - Unexpected bipolar flagellar arrangements and long-range flows driven by bacteria near ... 3370026 - Effects of flow pulsatility on platelet adhesion to subendothelium. 6671986 - Flow disturbance measurements through a constricted tube at moderate reynolds numbers. 2548786 - Place of the extra-intra-cranial-bypass in aneurysm-surgery. 19213936 - Cardiovascular and pulmonary consequences of airway recruitment in preterm lambs. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Artificial organs Volume: 27 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-06-03 Completed Date: 2003-10-02 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
|
Languages: eng Pagination: 517-29 Citation Subset: IM |
Affiliation:
|
Helmholtz-Institute for Biomedical Engineering, RWTH Aachen, Aachen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Artificial Organs / adverse effects* Blood Cells / physiology* Blood Flow Velocity Equipment Design Hemolysis / physiology* Models, Cardiovascular Shear Strength* Stress, Mechanical Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Study of the different types of actuators and mechanisms for upper limb prostheses.
Next Document: Extracorporeal gas exchange with the DeltaStream rotary blood pump in experimental lung injury.