| Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. | |
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MedLine Citation:
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PMID: 23202270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in γδ T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes. |
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Authors:
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Nadia R Cohen; Patrick J Brennan; Tal Shay; Gerald F Watts; Manfred Brigl; Joonsoo Kang; Michael B Brenner; |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-12-02 |
Journal Detail:
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Title: Nature immunology Volume: 14 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-14 Completed Date: 2013-03-01 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 90-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity
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genetics Animals Cell Differentiation Cell Lineage Genome, Human / immunology Humans Immunity, Innate / genetics Immunologic Memory / genetics Mice Microarray Analysis Natural Killer T-Cells / immunology* T-Lymphocyte Subsets / immunology* Thymus Gland / growth & development, immunology* Transcriptome* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI028973/AI/NIAID NIH HHS; R01AI063428/AI/NIAID NIH HHS; R24AI072073/AI/NIAID NIH HHS; T32AI007306/AI/NIAID NIH HHS |
| Investigator | |
Investigator/Affiliation:
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Paul Monach / ; Susan A Shinton / ; Richard R Hardy / ; Radu Jianu / ; David Koller / ; Jim Collins / ; Roi Gazit / ; Brian S Garrison / ; Derrick J Rossi / ; Kavitha Narayan / ; Katelyn Sylvia / ; Joonsoo Kang / ; Anne Fletcher / ; Kutlu Elpek / ; Angelique Bellemare-Pelletier / ; Deepali Malhotra / ; Shannon Turley / ; Adam J Best / ; Jamie Knell / ; Ananda Goldrath / ; Vladimir Jojic / ; Daphne Koller / ; Tal Shay / ; Aviv Regev / ; Nadia Cohen / ; Patrick Brennan / ; Michael Brenner / ; Taras Kreslavsky / ; Natalie A Bezman / ; Joseph C Sun / ; Charlie C Kim / ; Lewis L Lanier / ; Jennifer Miller / ; Brian Brown / ; Miriam Merad / ; Emmanuel L Gautier / ; Claudia Jakubzick / ; Gwendalyn J Randolph / ; Francis Kim / ; Tata Nageswara Rao / ; Amy Wagers / ; Tracy Heng / ; Michio Painter / ; Jeffrey Ericson / ; Scott Davis / ; Ayla Ergun / ; Michael Mingueneau / ; Diane Mathis / ; Christophe Benoist / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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