Document Detail

Shared and distinct genetic influences among different measures of pulmonary function.
MedLine Citation:
PMID:  23299959     Owner:  NLM     Status:  MEDLINE    
We examined shared and distinct genetic influences among standard measures of pulmonary functions: ratio of forced expiratory volume at 1 s to forced vital capacity (FEV1/FVC) and percent predicted values for forced expiratory volume at 1 s (FEV1%p), forced expiratory flow (FEFmax%p), and maximal voluntary ventilation (MVV%p) in 978-1,048 middle-aged (mean age = 55 years) male-male twins from the Vietnam Era Twin Study of Aging. A common latent factor (h(2) = 0.30) accounted for the correlations among these measures. This factor accounted for 54-81 % of the heritability of FEV1%p, FEFmax%p and MVV%p, but only explained 16 % of the heritability of FEV1/FVC. The remaining heritability of FEV1/FVC was explained by genetic influences independent of the common factor. Our findings suggest that while a common latent phenotype accounts for the relationships among different pulmonary function measures, the majority of genetic influences underlying FEV1/FVC--an index of pulmonary obstruction--are distinct from those underlying other pulmonary function measures.
Terrie Vasilopoulos; Michael D Grant; Carol E Franz; Matthew S Panizzon; Hong Xian; Rosemary Toomey; Michael J Lyons; William S Kremen; Kristen C Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Twin Study     Date:  2013-01-09
Journal Detail:
Title:  Behavior genetics     Volume:  43     ISSN:  1573-3297     ISO Abbreviation:  Behav. Genet.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-11-13     Revised Date:  2014-06-16    
Medline Journal Info:
Nlm Unique ID:  0251711     Medline TA:  Behav Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-50     Citation Subset:  IM    
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MeSH Terms
Forced Expiratory Volume / genetics*
Middle Aged
Respiratory Function Tests
Twins, Dizygotic
Twins, Monozygotic
Vital Capacity / genetics*
Grant Support
F32AG039954/AG/NIA NIH HHS; R01 AG018384/AG/NIA NIH HHS; R01 AG018386/AG/NIA NIH HHS; R01 AG022381/AG/NIA NIH HHS; R01 AG022982/AG/NIA NIH HHS; R01AG018384/AG/NIA NIH HHS; R01AG018386/AG/NIA NIH HHS; R01AG022381/AG/NIA NIH HHS; R01AG022982/AG/NIA NIH HHS

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