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Shared and Distinct Genetic Influences Among Different Measures of Pulmonary Function.
MedLine Citation:
PMID:  23299959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We examined shared and distinct genetic influences among standard measures of pulmonary functions: ratio of forced expiratory volume at 1 s to forced vital capacity (FEV1/FVC) and percent predicted values for forced expiratory volume at 1 s (FEV1%p), forced expiratory flow (FEFmax%p), and maximal voluntary ventilation (MVV%p) in 978-1,048 middle-aged (mean age = 55 years) male-male twins from the Vietnam Era Twin Study of Aging. A common latent factor (h(2) = 0.30) accounted for the correlations among these measures. This factor accounted for 54-81 % of the heritability of FEV1%p, FEFmax%p and MVV%p, but only explained 16 % of the heritability of FEV1/FVC. The remaining heritability of FEV1/FVC was explained by genetic influences independent of the common factor. Our findings suggest that while a common latent phenotype accounts for the relationships among different pulmonary function measures, the majority of genetic influences underlying FEV1/FVC-an index of pulmonary obstruction-are distinct from those underlying other pulmonary function measures.
Authors:
Terrie Vasilopoulos; Michael D Grant; Carol E Franz; Matthew S Panizzon; Hong Xian; Rosemary Toomey; Michael J Lyons; William S Kremen; Kristen C Jacobson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Behavior genetics     Volume:  -     ISSN:  1573-3297     ISO Abbreviation:  Behav. Genet.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0251711     Medline TA:  Behav Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue, MC 3077 CNPRU, Chicago, IL, 60637, USA, terriev@uchicago.edu.
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