| Shaping up nucleic acid computation. | |
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MedLine Citation:
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PMID: 20538451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acid-based nanotechnology has always been perceived as novel, but has begun to move from theoretical demonstrations to practical applications. In particular, the large address spaces available to nucleic acids can be exploited to encode algorithms and/or act as circuits and thereby process molecular information. In this review we not only revisit several milestones in the field of nucleic acid-based computation, but also highlight how the prospects for nucleic acid computation go beyond just a large address space. Functional nucleic acid elements (aptamers, ribozymes, and deoxyribozymes) can serve as inputs and outputs to the environment, and can act as logical elements. Into the future, the chemical dynamics of nucleic acids may prove as useful as hybridization for computation. |
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Authors:
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Xi Chen; Andrew D Ellington |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-09 |
Journal Detail:
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Title: Current opinion in biotechnology Volume: 21 ISSN: 1879-0429 ISO Abbreviation: Curr. Opin. Biotechnol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-28 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9100492 Medline TA: Curr Opin Biotechnol Country: England |
Other Details:
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Languages: eng Pagination: 392-400 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Nucleic Acid Conformation Nucleic Acids / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM077040/GM/NIGMS NIH HHS; R01 GM077040-08/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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