| Shaping fission yeast with microtubules. | |
| | |
MedLine Citation:
|
PMID: 20066076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
For cell morphogenesis, the cell must establish distinct spatial domains at specified locations at the cell surface. Here, we review the molecular mechanisms of cell polarity in the fission yeast Schizosaccharomyces pombe. These are simple rod-shaped cells that form cortical domains at cell tips for cell growth and at the cell middle for cytokinesis. In both cases, microtubule-based systems help to shape the cell by breaking symmetry, providing endogenous spatial cues to position these sites. The plus ends of dynamic microtubules deliver polarity factors to the cell tips, leading to local activation of the GTPase cdc42p and the actin assembly machinery. Microtubule bundles contribute to positioning the division plane through the nucleus and the cytokinesis factor mid1p. Recent advances illustrate how the spatial and temporal regulation of cell polarization integrates many elements, including historical landmarks, positive and negative controls, and competition between pathways. |
| | |
Authors:
|
Fred Chang; Sophie G Martin |
Related Documents
:
|
10982396 - Actin-dependent lamellipodia formation and microtubule-dependent tail retraction contro... 19759416 - Multiple localization of endogenous mark4l protein in human glioma. 7026576 - Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mam... 2879726 - Microtubules and the gonadotropic regulation of granulosa cell steroidogenesis. 9611806 - Fused nucleoids resegregate faster than cell elongation in escherichia coli pbpb(ts) fi... 21701706 - Flexible quantum dot sensitized solar cell by electrophoretic deposition of cdse quantu... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Cold Spring Harbor perspectives in biology Volume: 1 ISSN: 1943-0264 ISO Abbreviation: Cold Spring Harb Perspect Biol Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2010-01-12 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101513680 Medline TA: Cold Spring Harb Perspect Biol Country: United States |
Other Details:
|
Languages: eng Pagination: a001347 Citation Subset: IM |
Affiliation:
|
Columbia University, College of Physicians and Surgeons, Department of Microbiology, 701 W 168th Street, New York 10032, USA. fc99@columbia.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actins
/
chemistry Cell Cycle Cell Polarity Cytokinesis Cytoskeleton / metabolism Gene Expression Regulation, Fungal Green Fluorescent Proteins / chemistry Microtubules / metabolism* Models, Biological Mutation Schizosaccharomyces / physiology* cdc42 GTP-Binding Protein / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
GM069670/GM/NIGMS NIH HHS; GM56836/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Actins; 147336-22-9/Green Fluorescent Proteins; EC 3.6.5.2/cdc42 GTP-Binding Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left-Right Determination: Involvement of Molecular Motor KIF3, Cilia, and Nodal Flow.
Next Document: Physical model of cellular symmetry breaking.