| Shaping the T-cell repertoire in the periphery. | |
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MedLine Citation:
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PMID: 21079641 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self-reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens. The implications of peripheral T-cell selection for the immune response as animals age are discussed as is the critical role of dendritic cells in directing T-cell differentiation. |
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Authors:
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Stacey Allen; Stephen J Turner; Dorothée Bourges; Paul A Gleeson; Ian R van Driel |
Publication Detail:
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Type: Journal Article Date: 2010-11-16 |
Journal Detail:
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Title: Immunology and cell biology Volume: 89 ISSN: 1440-1711 ISO Abbreviation: Immunol. Cell Biol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706300 Medline TA: Immunol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 60-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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