Document Detail

Shape-selective extraction of PCBs and dioxins from fish and fish oil using in-cell carbon fractionation pressurized liquid extraction.
MedLine Citation:
PMID:  17343366     Owner:  NLM     Status:  MEDLINE    
This paper describes a new shape-selective, pressurized liquid extraction (PLE) procedure for extracting polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and PCBs from food and feed samples with an integrated carbon fractionation step. Initially this was done using specially designed inserts for 34-mL cells, but subsequently, large solid cells (66 mL) were machined to increase the capacity and robustness of the system. Depending on the carbon load and extraction solvent strength, the non-ortho PCBs were recovered either with the bulk of the PCBs or with the PCDD/Fs. The former is preferable if PCDD/Fs are the targets. In most cases, however, data are required for all indicator PCBs, WHO-PCBs, and PCDD/Fs. Therefore, further efforts focused on developing, optimizing, and validating a cost- and time-efficient PLE procedure that can extract these targets, separate non-ortho PCBs and PCDD/Fs from the bulk of the PCBs, allow gravimetric fat determinations, and requires a minimum of postextraction cleanup. The performance of the resulting procedure was assessed in experiments with a fish tissue reference material. The trueness of the WHO-PCB-TEQ, PCDD/F-TEQ, and total-TEQ data were -8, -5, and -7%, respectively, and the corresponding CVs were 1.5, 0.5, and 1.3%; within the limits set by the European community for gas chromatography-high-resolution mass spectrometry methods for food and feed control.
P Haglund; S Sporring; K Wiberg; E Björklund
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-08
Journal Detail:
Title:  Analytical chemistry     Volume:  79     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-06-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2945-51     Citation Subset:  IM    
Department of Chemistry, Umeå University, S-901 87 Umeå, Sweden.
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MeSH Terms
Benzofurans / analysis*
Carbon / chemistry*
Chromatography, Liquid / methods
Equipment Design
Fish Oils / chemistry*
Gas Chromatography-Mass Spectrometry / instrumentation,  methods
Particle Size
Polychlorinated Biphenyls / analysis*
Sensitivity and Specificity
Tetrachlorodibenzodioxin / analogs & derivatives*,  analysis
Reg. No./Substance:
0/Benzofurans; 0/Fish Oils; 0/Polychlorinated Biphenyls; 0/polychlorodibenzo-4-dioxin; 132-64-9/dibenzofuran; 1746-01-6/Tetrachlorodibenzodioxin; 7440-44-0/Carbon

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