Document Detail

Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints.
MedLine Citation:
PMID:  19815214     Owner:  NLM     Status:  MEDLINE    
With continued development and improvement of tissue engineering therapies for small articular lesions, increased attention is being focused on the challenge of engineering partial or whole synovial joints. Joint-scale constructs could have applications in the treatment of large areas of articular damage or in biological arthroplasty of severely degenerate joints. This review considers the roles of shape, loading and motion in synovial joint mechanobiology and their incorporation into the design, fabrication, and testing of engineered partial or whole joints. Incidence of degeneration, degree of impairment, and efficacy of current treatments are critical factors in choosing a target for joint bioengineering. The form and function of native joints may guide the design of engineered joint-scale constructs with respect to size, shape, and maturity. Fabrication challenges for joint-scale engineering include controlling chemo-mechano-biological microenvironments to promote the development and growth of multiple tissues with integrated interfaces or lubricated surfaces into anatomical shapes, and developing joint-scale bioreactors which nurture and stimulate the tissue with loading and motion. Finally, evaluation of load-bearing and tribological properties can range from tissue to joint scale and can focus on biological structure at present or after adaptation.
Gregory M Williams; Elaine F Chan; Michele M Temple-Wong; Won C Bae; Koichi Masuda; William D Bugbee; Robert L Sah
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-07
Journal Detail:
Title:  Journal of biomechanics     Volume:  43     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-05-13     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-65     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Biomedical Engineering / methods*
Cartilage, Articular / physiology*
Joints / physiology*
Stress, Mechanical
Synovial Membrane / metabolism*
Tissue Engineering
Tissue Scaffolds
Weight-Bearing / physiology
Grant Support
P01 AG007996/AG/NIA NIH HHS; P01 AG007996-160004/AG/NIA NIH HHS; P01 AG007996-17A28426/AG/NIA NIH HHS; R01 AR044058/AR/NIAMS NIH HHS; R01 AR044058-14/AR/NIAMS NIH HHS; R01 AR044058-14S1/AR/NIAMS NIH HHS; R01 AR051565/AR/NIAMS NIH HHS; R01 AR051565-04/AR/NIAMS NIH HHS; R01 AR051565-04S1/AR/NIAMS NIH HHS; R21 EB004905/EB/NIBIB NIH HHS; R21 EB004905-02/EB/NIBIB NIH HHS; //Howard Hughes Medical Institute

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