| Shape-dependent cytotoxicity and proinflammatory response of poly(3,4-ethylenedioxythiophene) nanomaterials. | |
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MedLine Citation:
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PMID: 20209653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(3,4-ethylenedioxythiophene) (PEDT) is recognized as one of the most promising conducting polymers for future applications in the fields of electronics, optics, energy storage/conversion, and biomedical science. The toxicity of PEDT could be considered to affect the potential for its widespread application. Herein, the cytotoxicity and proinflammatory response of PEDT nanomaterials of three different shapes toward human lung fibroblast (IMR90) and mouse alveolar macrophage (J774A.1) cells are investigated. The shape-dependent toxicity of the PEDT nanomaterials is evaluated by examining cell morphological change, cytotoxicity, apoptosis/necrosis, oxidative stress, and immune response. The cytotoxicity and apoptosis of the nanomaterials increase with their decreasing aspect ratio in both cell lines. The formation of reactive oxygen species in cells treated with PEDT nanomaterials is dependent on the shape and concentration of the nanomaterial. Proinflammatory cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor alpha from macrophages, are induced by PEDT nanomaterial-treated cells. |
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Authors:
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Wan-Kyu Oh; Sojin Kim; Hyeonseok Yoon; Jyongsik Jang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Small (Weinheim an der Bergstrasse, Germany) Volume: 6 ISSN: 1613-6829 ISO Abbreviation: Small Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-07-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235338 Medline TA: Small Country: Germany |
Other Details:
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Languages: eng Pagination: 872-9 Citation Subset: IM |
Affiliation:
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School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul 151-742, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Bicyclo Compounds, Heterocyclic / chemistry*, pharmacology* Cell Death / drug effects Cell Line Cell Shape / drug effects Cell Survival / drug effects Cytokines / genetics, metabolism Fibroblasts / cytology*, drug effects, metabolism Gene Expression Regulation / drug effects Humans Inflammation Mediators / pharmacology* Macrophages / cytology*, drug effects, metabolism Mice Nanostructures / chemistry*, ultrastructure Necrosis / pathology Polymers / chemistry*, pharmacology* Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bicyclo Compounds, Heterocyclic; 0/Cytokines; 0/Inflammation Mediators; 0/Polymers; 0/Reactive Oxygen Species; 0/poly(3,4-ethylene dioxythiophene) |
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