Document Detail


Shallow breathing: bacterial life at low O(2).
MedLine Citation:
PMID:  23411864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Competition for molecular oxygen (O(2)) among respiratory microorganisms is intense because O(2) is a potent electron acceptor. This competition leads to the formation of microoxic environments wherever microorganisms congregate in aquatic, terrestrial and host-associated communities. Bacteria can harvest O(2) present at low, even nanomolar, concentrations using high-affinity terminal oxidases. Here, we report the results of surveys searching for high-affinity terminal oxidase genes in sequenced bacterial genomes and shotgun metagenomes. The results indicate that bacteria with the potential to respire under microoxic conditions are phylogenetically diverse and intriguingly widespread in nature. We explore the implications of these findings by highlighting the importance of microaerobic metabolism in host-associated bacteria related to health and disease.
Authors:
Rachel L Morris; Thomas M Schmidt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  11     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-04-12     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aerobiosis
Anaerobiosis
Bacteria / enzymology,  growth & development*,  metabolism*
Bacterial Physiological Phenomena*
Energy Metabolism*
Oxidation-Reduction
Oxidoreductases / genetics,  metabolism
Oxygen / metabolism*
Grant Support
ID/Acronym/Agency:
R01 GM099549/GM/NIGMS NIH HHS; R01 HG004906/HG/NHGRI NIH HHS; R01 HG004906/HG/NHGRI NIH HHS; UH3 DK083993/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
EC 1.-/Oxidoreductases; S88TT14065/Oxygen
Comments/Corrections

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