| Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. | |
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MedLine Citation:
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PMID: 20558665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adipose tissue secretes proteins referred to as adipokines, many of which promote inflammation and disrupt glucose homeostasis. Here we show that secreted frizzled-related protein 5 (Sfrp5), a protein previously linked to the Wnt signaling pathway, is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes. Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages that was associated with activation of the c-Jun N-terminal kinase signaling pathway. Adenovirus-mediated delivery of Sfrp5 to mouse models of obesity ameliorated glucose intolerance and hepatic steatosis. Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue. |
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Authors:
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Noriyuki Ouchi; Akiko Higuchi; Koji Ohashi; Yuichi Oshima; Noyan Gokce; Rei Shibata; Yuichi Akasaki; Akihiko Shimono; Kenneth Walsh |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-17 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 329 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-09 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 454-7 Citation Subset: IM |
Affiliation:
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Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA. nouchi@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Adipocytes / metabolism*, pathology Adipokines / genetics, metabolism* Adipose Tissue / metabolism*, pathology Animals Dietary Fats / administration & dosage Dietary Sucrose / administration & dosage Fatty Liver / pathology, therapy Genetic Vectors Glucose / metabolism Humans Inflammation Insulin / metabolism Insulin Resistance Intercellular Signaling Peptides and Proteins / genetics, metabolism* Macrophages / metabolism* Mice Mice, Inbred C57BL Mice, Obese Mitogen-Activated Protein Kinase 8 / genetics, metabolism Obesity / metabolism*, pathology Phosphorylation Rats Rats, Zucker Signal Transduction Wnt Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG15052/AG/NIA NIH HHS; AG34972/AG/NIA NIH HHS; HL81587/HL/NHLBI NIH HHS; HL86785/HL/NHLBI NIH HHS; P01 HL081587-05/HL/NHLBI NIH HHS; R01 AG015052-06/AG/NIA NIH HHS; R01 AG034972-03/AG/NIA NIH HHS; R01 HL086785-19/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/Dietary Fats; 0/Dietary Sucrose; 0/Intercellular Signaling Peptides and Proteins; 0/Sfrp5 protein, mouse; 0/Wnt Proteins; 0/Wnt5a protein, mouse; 11061-68-0/Insulin; 50-99-7/Glucose; EC 2.7.11.24/Mitogen-Activated Protein Kinase 8 |
| Comments/Corrections | |
Comment In:
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Nat Rev Drug Discov. 2010 Aug;9(8):594
[PMID:
20671761
]
Science. 2010 Jul 23;329(5990):397-8 [PMID: 20651140 ] Nat Rev Immunol. 2010 Aug;10(8):540 [PMID: 20672476 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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