Document Detail


Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis.
MedLine Citation:
PMID:  16467359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regulation of Wnt signaling is essential for embryonic patterning. Sfrps are secreted Wnt antagonists that directly interact with the Wnt ligand to inhibit signaling. Here, we show that Sfrp1 and Sfrp2 are required for anteroposterior (AP) axis elongation and somitogenesis in the thoracic region during mouse embryogenesis. Double homozygous mutations in Sfrp1 and Sfrp2 lead to severe shortening of the thoracic region. By contrast, a homozygous mutation in one or the other exerts no effect on embryogenesis, indicating that Sfrp1 and Sfrp2 are functionally redundant. The defect of a shortened thoracic region appears to be the consequence of AP axis reduction and incomplete somite segmentation. The reduction in the AP axis is partially due to abnormalities in cell migration of pre-somitic mesoderm from the end of gastrulation. Aberrant somite segmentation is associated with altered oscillations of Notch signaling, as evidenced by abnormal Lfng and Hes7 expression during somitogenesis in the thoracic region. This study suggests that Wnt regulation by Sfrp1 and Sfrp2 is required for embryonic patterning.
Authors:
Wataru Satoh; Takafumi Gotoh; Yasuhiko Tsunematsu; Shinichi Aizawa; Akihiko Shimono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-08
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  133     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  989-99     Citation Subset:  IM    
Affiliation:
Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuou-ku, Kobe 650-0047, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / metabolism*
Biological Clocks
Body Patterning
Cell Differentiation
Cells, Cultured
Embryo Culture Techniques
Embryonic Development*
Extremities / embryology
Gene Expression Regulation, Developmental
Intercellular Signaling Peptides and Proteins / deficiency,  genetics,  metabolism*
Membrane Proteins / deficiency,  genetics,  metabolism*
Mice
Mice, Knockout
Mutation / genetics
Receptors, Notch / metabolism
Signal Transduction
Somites / cytology,  metabolism*
Wnt Proteins / metabolism
beta Catenin / metabolism
Chemical
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Receptors, Notch; 0/Sfrp1 protein, mouse; 0/Sfrp2 protein, mouse; 0/Wnt Proteins; 0/beta Catenin

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