| Sexually arousing events and relapse to heroin-seeking in sexually experienced male rats. | |
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MedLine Citation:
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PMID: 9035267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have shown previously, using a reinstatement procedure, that both priming injections of heroin and exposure to footshock stress reinstate heroin-taking behavior following prolonged drug-free periods. In the present study, we examined the effect of another highly arousing event, exposure to a sexually active female, on reinstatement of heroin-seeking. Male rats were first given sexual experience, being allowed to copulate on 4 occasions with sexually active females and were then trained to self-administer heroin (100 micrograms/kg per infusion, IV) for 4 3-h sessions/day for 5-6 days and 1 6-h session/day for an additional 6 days. Extinction sessions were then given for 4 days, 6-h/day, during which saline was substituted for heroin. On tests for reinstatement, males were presented with: 1. The wire-mesh side of an empty cage (baseline condition), 2. the sight, odor, and smell of a sexually inactive female, 3. the sight, odor, and smell of a female in heat, 4. a female in heat, and allowed to copulate, 5. intermittent footshock (15 min, 0.5 mA, 0.5 s on, mean off period of 40 s), or 6. a priming injection of heroin (0.25 mg/kg, SC). Reinstatement of heroin-taking behavior was observed after exposure to the priming injection of heroin and to footshock stress. Reinstatement of heroin-taking behavior was not induced by exposure to the females in any of the conditions. Thus, motivational arousal, as such, does not appear to be a sufficient stimulus for relapse to heroin-taking. |
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Authors:
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Y Shaham; J Puddicombe; J Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 61 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-04-30 Completed Date: 1997-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 337-41 Citation Subset: IM |
Affiliation:
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Department of Psychology, Concordia University, Montreal, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arousal / drug effects Copulation / drug effects Extinction, Psychological / drug effects Female Heroin / pharmacology* Heroin Dependence / psychology* Libido / drug effects* Male Motivation* Rats Sexual Behavior, Animal / drug effects* |
| Chemical | |
Reg. No./Substance:
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561-27-3/Heroin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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