| Sexual violence, HSV-2 and HIV are important predictors for infertility in Rwanda. | |
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MedLine Citation:
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PMID: 20685757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In order to formulate cost-effective health interventions aimed at preventing infertility it is necessary to identify modifiable risk factors for infertility in sub-Saharan Africa. This case-control study examined potential predictors and their population attributable fraction (PAF%) for various infertility types including lifestyle factors, sexual behaviour and reproductive tract infections (RTIs). METHODS: Sexually active women aged 21-45 year presenting with infertility problems at the infertility clinic of the Kigali University Teaching Hospital (n = 312), and fertile controls who recently delivered (n = 283) were surveyed together with their male partners. Participants were interviewed about socio-demographic characteristics, sexual behaviours and lifestyle factors, and were tested for HIV and RTIs. RESULTS: Variables significantly associated with tubal infertility were history of sexual violence [adjusted odds ratio (AOR) 2.41; 95% CI 1.36-4.25]; positive HIV (AOR 2.41; 95% CI 1.36-4.25), herpes simplex virus type 2 (HSV-2; AOR 1.67; 95% CI 1.03-2.71) and Chlamydia trachomatis serology (AOR 1.78; 95% CI 0.99-3.21), and current bacterial vaginosis by Amsel criteria (AOR 1.97; 95% CI 1.12-3.47). Among men, male factor infertility was associated with positive HIV (AOR 2.43; 95% CI 1.31-5.23) and HSV-2 serology (AOR 1.71; 95% CI 1.02-2.87) and current urologic abnormalities (AOR 2.38; 95% CI 1.01-5.31). Positive HSV-2 serostatus carried the greatest PAF% (26%) for tubal infertility, followed by positive HIV serostatus (20%) and history of sexual violence (17%). CONCLUSIONS: Although temporal relationships are difficult to ascertain, history of sexual violence, HSV-2 infection and HIV infection are important predictors of infertility in Rwanda. |
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Authors:
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N Dhont; J van de Wijgert; S Luchters; C Muvunyi; J Vyankandondera; M Temmerman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-04 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 25 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2507-15 Citation Subset: IM |
Affiliation:
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International Centre for Reproductive Health, Ghent University, Ghent, Belgium. dhontnathalie@gmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chlamydia Infections / blood, epidemiology, microbiology Chlamydia trachomatis / isolation & purification Female HIV Infections / blood, epidemiology*, transmission Herpes Genitalis / blood, epidemiology*, transmission Herpesvirus 2, Human* Humans Infertility, Female / blood, epidemiology*, virology Infertility, Male / blood, epidemiology*, virology Male Middle Aged Rwanda / epidemiology Sex Offenses* Sexual Behavior / statistics & numerical data Vaginitis / epidemiology, virology Violence* Young Adult |
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