| Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells. | |
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MedLine Citation:
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PMID: 23040890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event. |
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Authors:
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Sara Gianella; Sanjay R Mehta; Jason A Young; Milenka V Vargas; Susan J Little; Douglas D Richman; Sergei L Kosakovsky Pond; Davey M Smith |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-03 |
Journal Detail:
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Title: Virology Volume: 434 ISSN: 1096-0341 ISO Abbreviation: Virology Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-10-30 Completed Date: 2013-01-17 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: United States |
Other Details:
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Languages: eng Pagination: 2-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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University of California San Diego, La Jolla, CA 92093-0679, USA. gianella@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cluster Analysis HIV Infections / transmission* HIV-1 / genetics, isolation & purification*, pathogenicity* Humans Male Molecular Sequence Data Phylogeny RNA, Viral / genetics* Receptors, CXCR4 / metabolism Receptors, HIV / metabolism Semen / virology* Sequence Analysis, DNA Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AI043638/AI/NIAID NIH HHS; AI047745/AI/NIAID NIH HHS; AI077304/AI/NIAID NIH HHS; AI080353/AI/NIAID NIH HHS; AI36214/AI/NIAID NIH HHS; AI69432/AI/NIAID NIH HHS; AI74621/AI/NIAID NIH HHS; GM093939/GM/NIGMS NIH HHS; MH083552/MH/NIMH NIH HHS; MH62512/MH/NIMH NIH HHS; R01 AI047745/AI/NIAID NIH HHS; R01 GM093939/GM/NIGMS NIH HHS; R01 MH083552/MH/NIMH NIH HHS; R21 AI077304/AI/NIAID NIH HHS; R21 AI080353/AI/NIAID NIH HHS; U01 AI043638/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CXCR4 protein, human; 0/RNA, Viral; 0/Receptors, CXCR4; 0/Receptors, HIV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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