Document Detail


Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells.
MedLine Citation:
PMID:  23040890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event.
Authors:
Sara Gianella; Sanjay R Mehta; Jason A Young; Milenka V Vargas; Susan J Little; Douglas D Richman; Sergei L Kosakovsky Pond; Davey M Smith
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Virology     Volume:  434     ISSN:  1096-0341     ISO Abbreviation:  Virology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-01-17     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cluster Analysis
HIV Infections / transmission*
HIV-1 / genetics,  isolation & purification*,  pathogenicity*
Humans
Male
Molecular Sequence Data
Phylogeny
RNA, Viral / genetics*
Receptors, CXCR4 / metabolism
Receptors, HIV / metabolism
Semen / virology*
Sequence Analysis, DNA
Young Adult
Grant Support
ID/Acronym/Agency:
AI043638/AI/NIAID NIH HHS; AI047745/AI/NIAID NIH HHS; AI077304/AI/NIAID NIH HHS; AI080353/AI/NIAID NIH HHS; AI36214/AI/NIAID NIH HHS; AI69432/AI/NIAID NIH HHS; AI74621/AI/NIAID NIH HHS; GM093939/GM/NIGMS NIH HHS; K23 AI093163/AI/NIAID NIH HHS; M01 RR000827/RR/NCRR NIH HHS; MH083552/MH/NIMH NIH HHS; MH62512/MH/NIMH NIH HHS; P01 AI074621/AI/NIAID NIH HHS; P30 AI036214/AI/NIAID NIH HHS; R01 AI047745/AI/NIAID NIH HHS; R01 GM093939/GM/NIGMS NIH HHS; R01 MH083552/MH/NIMH NIH HHS; R21 AI077304/AI/NIAID NIH HHS; R21 AI080353/AI/NIAID NIH HHS; U01 AI043638/AI/NIAID NIH HHS; U01 AI069432/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/CXCR4 protein, human; 0/RNA, Viral; 0/Receptors, CXCR4; 0/Receptors, HIV
Comments/Corrections

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