Document Detail

Sexual organogenesis and circulating androgens in the rabbit fetus. Study after active immunization of mothers against testosterone (author's transl)
MedLine Citation:
PMID:  7458317     Owner:  NLM     Status:  MEDLINE    
The circulating level of free androgens (testosterone and dihydrotestosterone) in fetal rabbit was reduced by active immunization of mothers against testosterone. The level of testosterone and dihydrotestosterone binding to circulating proteins was about 100% in immunized fetuses and newborns. The testosterone and dihydrotestosterone binding capacities were higher than their circulating concentrations. Macroscopically, all newborns exhibited feminine external genitalia. Histological examinations showed the presence of complete wolffian ducts differentiated in epididymis, deferent ducts and seminal vesicles with normal structure. Prostatic development was strongly inhibited; anterior prostates were present but lateral and posterior prostates were frequently absent. In most animals the masculinization of the genital tubercle was prevented: 60% of males exhibited feminine external genitalia, 40% severe hypospadias. These results suggest: 1 degrees that fetal free circulating androgens (testosterone and/or dihydrotestosterone) induced masculinization of urogenital sinus and genital tubercle; 2 degrees that testicular testosterone was responsible for stabilization and differentiation of the wolffian duct.
G Veyssière; M Corre; M Berger; C Jean-Faucher; M de Turckheim; C Jean
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Archives d'anatomie microscopique et de morphologie expérimentale     Volume:  69     ISSN:  0003-9594     ISO Abbreviation:  Arch Anat Microsc Morphol Exp     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406007     Medline TA:  Arch Anat Microsc Morphol Exp     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  17-28     Citation Subset:  IM    
Vernacular Title:
Androgènes circulants et organogenèse sexuelle mâle chez le foetus de lapin. Etude après immunisation active de la mère contre la testostérone.
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MeSH Terms
Androgens / blood*
Fetal Blood / analysis
Genitalia, Male / embryology*
Testosterone / immunology*
Reg. No./Substance:
0/Androgens; 58-22-0/Testosterone

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