| Sexual isolation of male moths explained by a single pheromone response QTL containing four receptor genes. | |
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MedLine Citation:
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PMID: 20404144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long distance sexual communication in moths has fascinated biologists because of the complex, precise female pheromone signals and the extreme sensitivity of males to specific pheromone molecules. Progress has been made in identifying some genes involved in female pheromone production and in male response. However, we have lacked information on the genetic changes involved in evolutionary diversification of these mate-finding mechanisms that is critical to understanding speciation in moths and other taxa. We used a combined quantitative trait locus (QTL) and candidate gene approach to determine the genetic architecture of sexual isolation in males of two congeneric moths, Heliothis subflexa and Heliothis virescens. We report behavioral and neurophysiological evidence that differential male responses to three female-produced chemicals (Z9-14:Ald, Z9-16:Ald, Z11-16:OAc) that maintain sexual isolation of these species are all controlled by a single QTL containing at least four odorant receptor genes. It is not surprising that pheromone receptor differences could control H. subflexa and H. virescens responses to Z9-16:Ald and Z9-14:Ald, respectively. However, central rather than peripheral level control over the positive and negative responses of H. subflexa and H. virescens to Z11-16:OAc had been expected. Tight linkage of these receptor genes indicates that mutations altering male response to complex blends could be maintained in linkage disequilibrium and could affect the speciation process. Other candidate genes such as those coding for pheromone binding proteins did not map to this QTL, but there was some genetic evidence of a QTL for response to Z11-16:OH associated with a sensory neuron membrane protein gene. |
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Authors:
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Fred Gould; Marie Estock; N Kirk Hillier; Bekah Powell; Astrid T Groot; Catherine M Ward; Jennifer L Emerson; Coby Schal; Neil J Vickers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-04-19 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-06-02 Revised Date: 2010-11-12 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8660-5 Citation Subset: IM |
Affiliation:
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Department of Entomology and W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA. fred_gould@ncsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Structures
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drug effects,
physiology Animals Chromosome Mapping Chromosomes / genetics Crosses, Genetic Electrophysiological Phenomena / drug effects Female Genes, Insect / genetics* Inbreeding Ketones / pharmacology Male Moths / drug effects*, genetics* Neurons / drug effects, physiology Pheromones / pharmacology* Quantitative Trait Loci / genetics* Receptors, Odorant / genetics* Sexual Behavior, Animal / drug effects* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/11-hexadecenyl trifluoromethyl ketone; 0/Ketones; 0/Pheromones; 0/Receptors, Odorant |
| Comments/Corrections | |
Comment In:
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Proc Natl Acad Sci U S A. 2010 May 25;107(21):9481-2
[PMID:
20483990
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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