Document Detail

Sexual function in chronic kidney disease.
MedLine Citation:
PMID:  17395114     Owner:  NLM     Status:  MEDLINE    
Endocrine abnormalities are common in patients with chronic kidney disease (CKD) and lead to sexual dysfunction, anemia, hyperparathyroidism, and altered mineral metabolism. Common clinical problems include disturbances in menstruation in women, erectile dysfunction in men, and decreased libido and infertility in both sexes. Organic factors tend to be prominent and are related to uremia and other comorbid illnesses. Psychological factors and depression may exacerbate the primary problem. Alterations in the hypothalamic-pituitary axis are seen early in CKD and tend to worsen after patients start dialysis. Hypogonadism plays a dominant role in male sexual function, whereas changes in hypothalamic-pituitary function predominate in female sexual dysfunction. In patients on dialysis, treatment strategies include optimizing dose of dialysis, correction of anemia with erythropoietin, and correction of hyperparathyroidism. Successful kidney transplantation may restore normal sexual function, especially in younger patients.
Priya Anantharaman; Rebecca J Schmidt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in chronic kidney disease     Volume:  14     ISSN:  1548-5595     ISO Abbreviation:  -     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101209214     Medline TA:  Adv Chronic Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
West Virginia University School of Medicine, Morgantown, WV 26505, USA.
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MeSH Terms
Androgens / administration & dosage,  adverse effects
Chronic Disease
Erythropoietin, Recombinant / therapeutic use
Hormone Replacement Therapy
Hypogonadism / complications
Kidney Diseases / complications*,  therapy
Kidney Transplantation
Phosphodiesterase Inhibitors / therapeutic use
Piperazines / therapeutic use
Purines / therapeutic use
Sexual Dysfunction, Physiological / diagnosis,  etiology*,  therapy
Sulfones / therapeutic use
Testosterone / administration & dosage,  adverse effects,  deficiency
Reg. No./Substance:
0/Androgens; 0/Erythropoietin, Recombinant; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil; 58-22-0/Testosterone

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