Document Detail

Sexual dimorphism of sodium-sensitive renal-wrap hypertension.
MedLine Citation:
PMID:  9323002     Owner:  NLM     Status:  MEDLINE    
One-kidney, figure-8 renal wrap or sham operation was performed on male and female rats to determine if a difference existed in the expression of hypertension between the sexes. Animals were prepared with radiotelemetry transmitters to monitor mean arterial pressure and heart rate continuously throughout an 8-week study. Dietary sodium content was changed during the post-renal-wrap period from normal (100 micromol/g chow) to high (2000 micromol/g chow) to low (<2 micromol/g chow) to assess sodium sensitivity. Both male and female rats experienced an increase in arterial pressure after the renal-wrap procedure; however, the hypertension was significantly attenuated in the females. High salt caused a further increase in both groups of rats that was again attenuated in the female rats. Low sodium diet reduced arterial pressure in all groups of rats. Heart rate was significantly elevated in the female rats during all dietary interventions. The data were fit to a cosine function to analyze circadian rhythm changes. An increase in the light/dark difference for arterial pressure in the hypertensive rats during high salt diet resulted in an increase in the circadian amplitude (range of the rhythm). In the normotensive rats fed a high salt diet, the arterial pressure acrophase (peak of rhythm) was delayed while the heart rate acrophase was shifted to an earlier time. These studies showed that female rats are protected against one-kidney, figure-8 renal-wrap hypertension and are less sensitive to the effects of sodium.
J R Haywood; C Hinojosa-Laborde
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  30     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  IM    
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764, USA.
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MeSH Terms
Blood Pressure
Body Weight
Heart Rate
Hypertension / etiology*
Rats, Sprague-Dawley
Sex Factors
Sodium, Dietary / administration & dosage*
Grant Support
Reg. No./Substance:
0/Sodium, Dietary

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