| Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight, children as well as adolescents. | |
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MedLine Citation:
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PMID: 11641748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To demonstrate sexual dimorphism in serum leptin levels not only during puberty, but also in childhood in Japan. DESIGN: Cross-sectional study. SETTING: Hamamatsu-Hokuen study in Japan. SUBJECTS: Body weight and height were measured in normal-weight Japanese children and adolescents (143 boys, 178 girls), and 161 boys and 129 girls whose percentage of overweight for the standard (%Wt) was more than+25%. Serum leptin levels were compared with %Wt. Subjects were divided into group 1 (6-10 y of age) and group 2 (11-15 y of age) according to their age. RESULTS: In overweight subjects, leptin was more highly correlated with %Wt in boys of group 2 (r=0.67, P<0.0001) than group 1 (r=0.32, P=0.004). In girls as well, a correlation coefficient was greater in group 2 (r=0.67, P<0.0001) than group 1 (r=0.44, P=0.0011). In normal-weight boys, there was no significant correlation between serum leptin and %Wt both in groups 1 and 2. On the contrary, statistical significance was demonstrated in the correlation between serum leptin and %Wt in group 1 (r=0.31, P=0.0019) and group 2 (r=0.35, P=0.0014) as well as in the total normal-weight girls (r=0.28, P=0.0011). CONCLUSIONS: It is suggested that sexual dimorphism is present in serum leptin levels, especially when compared to weight, as early as during childhood. |
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Authors:
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T Nakanishi; R Li; Z Liu; M Yi; Y Nakagawa; T Ohzeki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 55 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-19 Completed Date: 2001-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 989-93 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Body Composition Body Weight / physiology* Child Cross-Sectional Studies Female Humans Leptin / blood* Male Obesity / blood* Puberty / blood Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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