Document Detail

Sexual dimorphism of gonadal development.
MedLine Citation:
PMID:  17875486     Owner:  NLM     Status:  MEDLINE    
Sexual dimorphism is a term describing morphological differences between the sexes, but is often extended to include all differences observed between females and males. Sex differentiation in vertebrates is by definition sexually dimorphic and starts at the level of the sex chromosomes. In this review the sexual dimorphism of gonadal differentiation is discussed, with a focus on human development. In the embryo, the indifferent gonadal anlagen harbours four different cell lineages with bipotential fates dependent on the sex of the individual. The different paths taken by these cell lineages in male and female development are reviewed, along with other sexually dimorphic features of gonadal development. These include sex-determining genes, timing of events, dependence on germ cells, spatial organization of stromal cells, steroidogenic cells types, and other aspects.
Olle Söder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  21     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  381-91     Citation Subset:  IM    
Department of Woman and Child Health, Paediatric Endocrinology Unit, Karolinska Institutet & University Hospital, SE-11130 Stockholm, Sweden.
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MeSH Terms
Cell Lineage / physiology
Fetal Organ Maturity / genetics
Gametogenesis / physiology
Gene Expression Regulation, Developmental
Genes, Homeobox
Germ Cells / physiology
Gonadal Steroid Hormones / biosynthesis,  pharmacology
Sex Characteristics*
Sex Determination (Genetics)*
Sex Differentiation*
Urogenital System / cytology,  embryology*
Reg. No./Substance:
0/Gonadal Steroid Hormones

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