| Sexual dimorphism of cardiovascular responses to early blockade of bradykinin receptors. | |
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MedLine Citation:
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PMID: 8613235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess whether the cardiovascular effects induced by early blockade of bradykinin B2-receptors with Hoe 140 (D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin) are influenced by sex, Wistar rats of both sexes received the antagonist (300 nmol/d per kilogram body wt) or vehicle from 2 days to 7 weeks of age by subcutaneous injection and then by intraperitoneal infusion. Compared with control rats, Hoe 140-treated female rats showed higher systolic blood pressure levels at 7 and 9 weeks of age (125 +/- 2 versus 111 +/- 2 mm Hg and 132 +/- 3 versus 116 +/- 2 mm Hg, respectively, P < .05), whereas in male rats a difference was found at 7 weeks (122 +/- 4 versus 108 +/- 4 mm Hg, P < .05) but not at 9 weeks. At this stage, the mean blood pressure of Hoe 140-treated rats was higher than that of control animals, and this difference was more pronounced at 12 weeks in female rats (121 +/- 2 versus 100 +/- 3 mm Hg in control animals, P < .01) compared with males (116 +/- 3 versus 104 +/- 2 mm Hg in control animals, P < .05). After the first week of life, body weight gain was greater in Hoe 140-treated female rats than in control rats, whereas a group-difference was detected in male rats only after weaning. In Hoe 140-treated female rats, heart weight was already increased at 9 weeks (330 +/- 6 versus 305 +/- 5 mg/100 g body wt in control rats, P < .05), whereas it was necessary to prolong Hoe 140 administration in male rats to develop heart hypertrophy (300 +/- 4 versus 275 +/- 4 mg/100 g body wt in control rats at 12 weeks, P < .05). Tissue kallikrein mRNA levels were higher in the kidney of adult female rats, whereas no sex difference was detected in the heart. The finding of a sexual dimorphism in the cardiovascular response to early blockade of bradykinin receptor suggests that endogenous kinins play a role in the regulation of cardiovascular function in both sexes, but they may be functionally more important in the female rat. |
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Authors:
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P Madeddu; P Pinna Parpaglia; V Anania; N Glorioso; C Chao; C Wang; J Chao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 27 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-06-05 Completed Date: 1996-06-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 746-51 Citation Subset: IM |
Affiliation:
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Clinica Medica, University of Sassari, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Body Weight / drug effects Bradykinin / administration & dosage, analogs & derivatives* Cardiovascular Physiological Phenomena* Female Kallikreins / analysis Male Rats Receptors, Bradykinin / antagonists & inhibitors, physiology* Sex Characteristics* |
| Grant Support | |
ID/Acronym/Agency:
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HL-29397/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Bradykinin; 130308-48-4/icatibant; 58-82-2/Bradykinin; EC 3.4.21.-/Kallikreins |
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