Document Detail


Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes.
MedLine Citation:
PMID:  23210685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neural sexual differentiation begins during embryogenesis and continues after birth for a variable amount of time depending on the species and brain region. Because gonadal hormones were the first factors identified in neural sexual differentiation, their role in this process has eclipsed investigation of other factors. Here, we use a mouse with a spontaneous translocation that produces four different unique sets of sex chromosomes. Each genotype has one normal X-chromosome and a unique second sex chromosome creating the following genotypes: XY(*x) , XX, XY(*) , XX(Y) (*) . This Y(*) mouse line is used by several laboratories to study two human aneuploid conditions: Turner and Klinefelter syndromes. As sex chromosome number affects behavior and brain morphology, we surveyed brain gene expression at embryonic days 11.5 and 18.5 to isolate X-chromosome dose effects in the developing brain as possible mechanistic changes underlying the phenotypes. We compared gene expression differences between gonadal males and females as well as individuals with one vs. two X-chromosomes. We present data showing, in addition to genes reported to escape X-inactivation, a number of autosomal genes are differentially expressed between the sexes and in mice with different numbers of X-chromosomes. Based on our results, we can now identify the genes present in the region around the chromosomal break point that produces the Y(*) model. Our results also indicate an interaction between gonadal development and sex chromosome number that could further elucidate the role of sex chromosome genes and hormones in the sexual differentiation of behavior.
Authors:
J T Wolstenholme; E F Rissman; S Bekiranov
Related Documents :
24221315 - Estimation of preferential pairing in tetraploid x diploid hybridizations.
23941555 - Atctf7 is required for establishment of sister chromatid cohesion and association of co...
23321615 - Mosaic copy number variation in schizophrenia.
12583595 - Sex and death: chd1z associated with high mortality in moorhens.
10720865 - Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin.
16453655 - Successive transposition explosions in drosophila melanogaster and reverse transpositio...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-10
Journal Detail:
Title:  Genes, brain, and behavior     Volume:  12     ISSN:  1601-183X     ISO Abbreviation:  Genes Brain Behav.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-08-09     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101129617     Medline TA:  Genes Brain Behav     Country:  England    
Other Details:
Languages:  eng     Pagination:  166-80     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aneuploidy
Animals
Brain / embryology,  metabolism*
Chromosome Breakpoints
Female
Gene Expression Profiling
Gene Expression Regulation, Developmental
Genes, X-Linked / genetics*
Genes, Y-Linked / genetics*
Genotype
Gonadal Steroid Hormones / genetics,  metabolism
Male
Mice
Mice, Mutant Strains
Oligonucleotide Array Sequence Analysis
Phenotype
Sex Chromosomes / genetics*
Sex Differentiation / genetics*
Transcription, Genetic
Translocation, Genetic
Grant Support
ID/Acronym/Agency:
F32 ES019404/ES/NIEHS NIH HHS; F32 ES019404/ES/NIEHS NIH HHS; R01 MH057759/MH/NIMH NIH HHS; R01 MH057759/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nanoscale Electrochemical Patterning Reveals the Active Sites for Catechol Oxidation at Graphite Sur...
Next Document:  Impregnation of Decamolybdocobaltate Heteropolyanions over ?-Alumina: Detailed Description of the Ph...