Document Detail


Sexual differentiation of brain and behavior: the zebra finch is not just a flying rat.
MedLine Citation:
PMID:  8252375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In rats and other mammals, sex differences in the brain and behavior result from differential secretions of gonadal steroid hormones during early critical periods of neural development. We review the experimental results that support current ideas about the mechanisms of sexual differentiation in mammals, and then apply the same experimental analysis to the study of sexual differentiation of the neural song circuit in the zebra finch (Poephila guttata), a passerine song bird. Administration of estrogen to young female zebra finches causes the female to develop a more masculine song system and to sing as an adult. This estrogenic masculinization is similar to that found for copulatory behavior in mammals. However, striking differences emerge in other aspects of the sexual differentiation process. Experiments that use endocrine agents to block the masculine development in genetic males have so far failed. Moreover, the brain of zebra finches has an unusually high expression of aromatase (estrogen synthetase) in the telencephalon, and estrogen synthesized in the brain from androgen is released into the general circulation. These results suggest that the brain is the primary source of estrogen in the body. If so, then a further understanding of sexual differentiation requires more information on the factors that regulate the cerebral synthesis of estrogen.
Authors:
A P Arnold; B A Schlinger
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Brain, behavior and evolution     Volume:  42     ISSN:  0006-8977     ISO Abbreviation:  Brain Behav. Evol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-13     Completed Date:  1994-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151620     Medline TA:  Brain Behav Evol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  231-41     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of California, Los Angeles 90024-1563.
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MeSH Terms
Descriptor/Qualifier:
Animals
Birds / physiology*
Brain / physiology*
Female
Gonadal Steroid Hormones / physiology
Male
Rats
Sex Differentiation / physiology*
Sexual Behavior, Animal / physiology*
Species Specificity
Vocalization, Animal / physiology
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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