Document Detail

Sexual activity with and without the use of sildenafil: risk of cardiovascular events in patients with heart disease.
MedLine Citation:
PMID:  15185897     Owner:  NLM     Status:  MEDLINE    
The data in the literature on the relationship between sexual activity, with and without the use of sildenafil, and the occurrence of cardiovascular events (ventricular arrhythmias, nonfatal myocardial infarction, stroke and death) have been reviewed in patients with heart disease. To date, only patients with ischemic heart disease (IHD) have been investigated. The prevalence of premature ventricular beats during sexual intercourse is similar to that observed during other daily activities. Therefore, sexual activity does not seem to have a relevant arrhythmogenic effect. The incidence of sustained ventricular tachycardia during sexual intercourse in unknown. The relative risk of nonfatal myocardial infarction is 2.7 in males and 1.3 in females; however, the absolute risk appears extremely low and is similar in normal subjects and in patients with and without IHD. The risk appears to be restricted to the 2-hour time period after sexual intercourse. The incidence of stroke during sexual intercourse appears very low, but clear data are lacking. The incidence of death during sexual activity is unknown; the few available data suggest that it is very low. Extramarital sexual intercourse seems to increase the risk of death. The incidence of cardiovascular events after sildenafil administration has been investigated in placebo-controlled studies in patients with IHD. The incidence of nonfatal myocardial infarction, stroke and death did not significantly differ between sildenafil-treated and placebo-treated patients; therefore, sildenafil does not appear contraindicated in subjects with IHD. However, the drug should be administered with caution in patients with recent myocardial infarction or stroke, in those with active coronary ischemia and in patients with episodes of heart failure. The drug is absolutely contraindicated in patients using nitrates.
Paolo Alboni; Katia Bettiol; Giuseppe Fucà; Federico Pacchioni; Salvatore Scarfò
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Italian heart journal : official journal of the Italian Federation of Cardiology     Volume:  5     ISSN:  1129-471X     ISO Abbreviation:  Ital Heart J     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-09     Completed Date:  2004-11-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909716     Medline TA:  Ital Heart J     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  343-9     Citation Subset:  IM    
Division of Cardiology and Arrhythmologic Center, Civic Hospital, Cento (FE), Italy.
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MeSH Terms
Cardiovascular Diseases / drug therapy,  epidemiology,  physiopathology
Erectile Dysfunction / drug therapy,  epidemiology,  physiopathology
Heart Rate / drug effects
Phosphodiesterase Inhibitors / therapeutic use*
Piperazines / therapeutic use*
Risk Factors
Sexual Behavior / drug effects*,  physiology*
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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