Document Detail

Sexual activity in hypertensive men.
MedLine Citation:
PMID:  12874608     Owner:  NLM     Status:  MEDLINE    
Erectile dysfunction is one of the major obstacles for noncompliance in the antihypertensive treatment. It has been shown that various antihypertensive drugs have a negative influence on sexual activity such as diuretics and beta-blockers. Thus, the purpose of the present study was to evaluate the effect of valsartan, an AT1-receptor antagonist, or its combination with hydrochlorothiazide on sexual activity in hypertensive patients. A total of 2202 patients (mean age 54+/-8 years) with hypertension systolic blood pressure (SBP)> or =140 mmHg, diastolic blood pressure (DBP)> or =95 mmHg), or with pretreated hypertension, were included in the present analysis. Blood pressure was measured at baseline, after 8 and 16 weeks, respectively. Sexual activity was assessed with a questionnaire at each of the three visits. Sexual activity (intercourse per week) was determined in three groups: controls (n=27; conventional therapy); valsartan group (n=1899); valsartan in combination with hydrochlorothiazide (n=276). There were 26 drop outs. SBP (-18.6 mmHg) and DBP (-11.6 mmHg) decreased significantly in all three groups. Sexual activity decreased slightly in controls from 1.3 to 0.9 times per week (NS), whereas it increased in the valsartan group from 1.0 to 1.6 times during follow-up (P<0.0001). Similarly, sexual activity increased in the combination group from 0.9 to 1.3 times per week during follow-up (P<0.0001). No sexual activity was reported by 467 (21%) of the 2202 patients at baseline and 154 (7%) at 16 weeks follow-up (P<0.05). Impaired sexual activity is common in hypertensive patients (app. 20%). Valsartan increases the rate of sexual intercourses per week, whereas conventional therapy affects sexual activity adversely.
A Della Chiesa; D Pfiffner; B Meier; O M Hess
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  17     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-22     Completed Date:  2003-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-21     Citation Subset:  IM    
Swiss Cardiovascular Center, University Hospital, Bern, Switzerland.
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MeSH Terms
Antihypertensive Agents / administration & dosage*,  adverse effects
Blood Pressure / drug effects
Drug Therapy, Combination
Hydrochlorothiazide / administration & dosage*,  adverse effects
Hypertension / drug therapy*,  physiopathology*
Middle Aged
Prospective Studies
Sexual Behavior / drug effects
Sodium Chloride Symporter Inhibitors / administration & dosage
Tetrazoles / administration & dosage*,  adverse effects
Valine / administration & dosage*,  adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Diuretics; 0/Sodium Chloride Symporter Inhibitors; 0/Tetrazoles; 137862-53-4/valsartan; 58-93-5/Hydrochlorothiazide; 7004-03-7/Valine

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