Document Detail


Sexual activity, erectile dysfunction, and incident cardiovascular events.
MedLine Citation:
PMID:  20102917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although erectile dysfunction (ED) is considered a well-established risk factor for cardiovascular disease (CVD), few studies have investigated whether other aspects of sexual function might predict CVD independently of ED. In a longitudinal, population-based study of community-dwelling men participating in the Massachusetts Male Aging Study, we examined sexual function variables (including ED) and the subsequent development of CVD. ED was defined according to a validated, discriminant-analytic formula determined from the questionnaire responses and categorized as moderate/complete ED versus none/minimal. CVD included a wide range of major end points and was ascertained through self-report, medical records, and the National Death Index. We calculated the age-adjusted incidence rates according to the person-years of follow-up, and Cox proportional hazards models were used to estimate covariate-adjusted, Framingham risk score-adjusted, and ED-adjusted hazard ratios and 95% confidence intervals for sexual function variables and the subsequent risk of CVD. Of the 1,165 men free of CVD at baseline, the age-adjusted CVD incidence rate for moderate/complete ED and none/minimal ED was 17.9/1,000 person-years and 12.5/1,000 person-years, respectively. In multivariate models adjusted for age, covariates, ED, and the Framingham risk score, a low frequency of sexual activity (once a month or less vs >or=2 times weekly) was associated with increased risk of CVD (hazard ratio 1.45, 95% confidence interval 1.04 to 2.01). In conclusion, our results suggest that a low frequency of sexual activity predicts CVD independently of ED and that screening for sexual activity might be clinically useful.
Authors:
Susan A Hall; Rebecca Shackelton; Raymond C Rosen; Andre B Araujo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
New England Research Institutes, Watertown, Massachusetts, USA. shall@neriscience.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Cardiovascular Diseases / epidemiology*
Case-Control Studies
Cohort Studies
Erectile Dysfunction / complications*
Humans
Incidence
Male
Massachusetts
Middle Aged
Personal Satisfaction
Risk Factors
Sexual Behavior*
Socioeconomic Factors
Grant Support
ID/Acronym/Agency:
AG04763/AG/NIA NIH HHS; DK44995/DK/NIDDK NIH HHS; DK51345/DK/NIDDK NIH HHS; R01 DK044995/DK/NIDDK NIH HHS; R01 DK044995-04/DK/NIDDK NIH HHS
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