Document Detail

Sexual Functioning in Patients With Recurrent Major Depressive Disorder Enrolled in the PREVENT Study.
MedLine Citation:
PMID:  23538970     Owner:  NLM     Status:  In-Data-Review    
The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to receive venlafaxine extended release (ER; 75-300 mg/day) or fluoxetine (20-60 mg/day). Sexual dysfunction was assessed using items from the 17-item Hamilton Rating Scale for Depression (HAM-D17) and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR). The baseline rates of sexual dysfunction based on the HAM-D17 and IDS-SR items were 57.9% and 48.8%, respectively. The rates of new-onset sexual dysfunction for the venlafaxine ER-treated (44.8%, HAM-D17; 38.4%, IDS-SR) and fluoxetine-treated patients (52.9%, HAM-D17; 50.0%, IDS-SR) were similar; approximately 80% of the cases resolved during treatment. Treatment response was associated with lower rates of new-onset sexual dysfunction compared with nonresponse. The patients who remitted were the least likely to experience sexual dysfunction during antidepressant treatment.
Alan J Gelenberg; David L Dunner; Anthony J Rothschild; Ron Pedersen; Kathleen M Dorries; Philip T Ninan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  201     ISSN:  1539-736X     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-73     Citation Subset:  AIM; IM    
*Penn State University, Hershey, PA; †Center for Anxiety and Depression, Mercer Island, WA; ‡University of Massachusetts Medical School and UMass Memorial Health Care, Worcester; §Pfizer, Collegeville, PA; and ∥Embryon, Somerville, NJ.
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